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WHO FOOD ADDITIVES SERIES: 47

Safety evaluation of certain mycotoxins in food

Prepared by the Fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)

FAO FOOD AND NUTRITION PAPER 74

Food and Agriculture Organization of the United Nations

2001World Health Organization, Geneva, 2001IPCS—International Programme on Chemical Safety

This publication is a contribution to the International Programme on Chemical Safety.

The International Programme on Chemical Safety (IPCS), established in 1980, is a joint venture of the United Nations Environment Programme (UNEP), the International Labour Organisation (ILO), and the World Health Organization (WHO). The overall objectives of the IPCS are to establish the scientific basis for assessing the risk to human health and the environment from exposure to chemicals, through international peer-review processes, as a prerequisite for the promotion of chemical safety, and to provide technical assistance in strengthening national capacities for the sound management of chemicals.

The Inter-Organization Programme for the Sound Management of Chemicals (IOMC) was established in 1995 by UNEP, ILO, the Food and Agriculture Organization of the United Nations, WHO, the United Nations Industrial Development Organization, and the Organisation for Economic Co-operation and Development (Partici-pating Organizations), following recommendations made by the 1992 United Nations Conference on Environment and Development to strengthen cooperation and increase coordination in the field of chemical safety. The purpose of the IOMC is to promote coordination of the policies and activities pursued by the Participating Organiza-tions, jointly or separately, to achieve the sound management of chemicals in relation to human health and the environment.

Health & Environment International, Ltd, by agreement with WHO, performed independent literature searches on some of the substa-nces on which data are summarized in this document in order to ensure that all relevant toxicological and related information was reviewed.

CONTENTS

Preface

Aflatoxin M1

Fumonisins

Ochratoxin A

Trichothecenes

Deoxynivalenol

T-2 and HT-2

Annexes

Annex 1 Reports and other documents resulting from previous meetings of the Joint FAO/WHO Expert Committee on Food Additives

Annex 2 Abbreviations used in the monographs

Annex 3 Participants in the fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives

 

PREFACE

The monographs contained in this volume were prepared at the fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met at WHO Headquarters in Geneva, Switzerland, 6–15 February 2001. These monographs summarize the data on selected mycotoxins reviewed by the Committee.

The fifty-sixth report of JECFA will be published by the World Health Organization in the WHO Technical Report Series. Reports and other documents resulting from previous meetings of JECFA are listed in Annex 1. Abbreviations used in the monographs are listed in Annex 2. The participants in the meeting are listed in Annex 3 of the present publication.

JECFA serves as a scientific advisory body to FAO, WHO, their Member States, and the Codex Alimentarius Commission, primarily through the Codex Committee on Food Additives and Contaminants and the Codex Committee on Residues of Veterinary Drugs in Foods, regarding the safety of food additives, residues of veterinary drugs, naturally occurring toxicants, and contaminants in food. Commit-tees accomplish this task by preparing reports of their meetings and publishing specifications or residue monographs and toxicological monographs on substances that they have considered.

The monographs contained in this volume are based on working papers that were prepared by working groups before the meeting. A special acknowledgement is given at the beginning of each monograph to those who prepared these working papers. The monographs were edited by E. Heseltine, Lajarthe, 24290 St Léon-sur-Vézère, France.

The preparation and editing of the monographs included in this volume were made possible through the technical and financial contributions of the Participating Organizations of the International Programme on Chemical Safety (IPCS), which supports the activities of JECFA.

The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the organizations participating in the IPCS concerning the legal status of any country, territory, city, or area or its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by those organizations in preference to others of a similar nature that are not mentioned.

Any comments or new information on the biological or toxicological properties of the compounds evaluated in this publication should be addressed to: Joint WHO Secretary of the Joint FAO/WHO Expert Committee on Food Additives, International Programme on Chemical Safety, World Health Organization, Avenue Appia, 1211 Geneva 27, Switzerland.
















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       Toxicological Abbreviations