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    WHO Pesticide Residues Series No. 5

    1975 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD

    THE MONOGRAPHS

    The evaluations contained in these monographs were prepared by the
    Joint Meeting of the FAO Working Party of Experts on Pesticide
    Residues and the WHO Expert Committee on Pesticide Residues that met
    in Geneva from 24 November to 3 December 1975. *

    World Health Organization
    Geneva
    1976

              

    * Pesticide Residues in Food: Report of the 1975 Joint Meeting of the
    FAO Working Party of Experts on Pesticide Residues and the WHO Expert
    Committee on Pesticide Residues, Wld Hlth Org. techn. Rep. Ser., No.
    592; FAO Plant Production and Protection Series, No. 1.

    These monographs are also issued by the Food and Agriculture
    Organization of the United Nations, Rome, as document AGP:1975/M/13.

    ISBN 92 4 166505 X

    (c) FAO and WHO 1976

    CONTENTS

    List of Attendees

    Introduction

    The Monographs

    Aldrin/dieldrin*

    Benomyl*

    Bioresmethrin

    Bromophos*

    Bromophos-ethyl*

    sec-Butylamine

    Carbaryl*

    Chlordimeform*

    Chlorobenzilate*

    Chlorpyrifos*

    Chlorpyrifos-methyl

    Coumaphos*

    Cyanofenphos

    Cyhexatin*

    2,4-D*

    Demeton*

    Diazinon*

    Disulfoton*

    Endosulfan*

    Endrin*

    Ethion*

    Fenthion*

    Heptachlor*

    Leptophos*

    Lindane*

    Malathion*

    Methidathion*

    Methomyl*

    Monocrotophos*

    Omethoate*

    Parathion-methyl*

    2-Phenylphenol*

    Phosalone*

    Quintozene*

    Thiabendazole*

    Thiophanate-methyl*

    Trichlorfon*

    ANNEX 1 - Recommendations concerning acceptable daily intakes and
    residue limits made at the 1975 meeting

    ANNEX 2 - Glossary

    ANNEX 3 - References

              

    * Addendum
    

    LIST OF ATTENDEES

    Members of the FAO Working Party of Experts on Pesticide Residues:

    Dr A. F. H. Besemer, Head, Pesticides Division, Plant Protection
    Service, Ministry of Agriculture, Wageningen, Netherlands

    Dr G. Bressau, Head, Pesticides Unit, Division of Food Chemistry, Max
    von Pettenkofer Institute, Federal Health Office, Berlin

    Mr F. Bro-Rasmussen, Head, Department of Pesticides and Contaminants,
    National Food Institute, Soborg, Denmark (Rapporteur)

    Dr K. A. McCully, Chief, Field Sciences Division, Health Protection
    Branch, Department of National Health and Welfare, Ottawa, Canada

    Mr J. T. Snelson, Pesticides Coordinator, Department of Agriculture,
    Canberra, ACT, Australia (Vice-Chairman)

    Dr C. Tomizawa, National Institute of Agricultural Sciences,
    Nishigahara, Kita-Ku, Tokyo, Japan

    Observer invited by FAO:

    Dr A. J. Pieters, Chairman, Codex Committee on Pesticide Residues

    Members of the WHO Expert Committee on Pesticide Residues:

    Dr W. F. Almeida, Director, Division of Animal Biology, Biological
    Institute, Sao Paulo, Brazil

    Dr V. Benes, Chief, Department of Toxicology and Reference Laboratory,
    Institute of Hygiene and Epidemiology, Prague, Czechoslovakia
    (Rapporteur)

    Dr G. V. Gracheva, All-Union Scientific Institute of Hygiene and
    Toxicology of Pesticides, Polymers and Plastics, Kiev, USSR

    Professor F. Coulston, Director, Institute of Comparative and Human
    Toxicology, Albany Medical College, Union University, Albany, NY, USA
    (Chairman)

    Professor D. V. Parke, Chairman, Department of Biochemistry,
    University of Surrey, Guildford, England

    Dr E. Poulsen,  Director, Institute of Toxicology, National Food
    Institute, Soborg, Denmark

    Mr Huai-chou Wang, Institute of Hygiene, Chinese Academy of Medical
    Sciences, Peking, China

    Secretariat:

    Dr R. L. Baron, National Environmental Research Center, Environmental
    Protection Agency, Research Triangle Park, NC, USA (Temporary Adviser)

    Dr R. Leski, Chemical Residues and Pollution Section, Joint FAO/IAEA
    Division of Atomic Energy in Agriculture, International Atomic Energy
    Agency, Vienna, Austria

    Dr F. C. Lu, Chief, Food Additives, WHO, Geneva, Switzerland (Joint
    Secretary)

    Mr A. F. Machin, Senior Research Officer, Central Veterinary
    Laboratory, Ministry of Agriculture, Weybridge, England (Consultant)

    Dr E. Middleton, Food Directorate, Health Protection Branch,
    Department of National Health and Welfare, Ottawa, Canada (Temporary
    Adviser)

    Dr E. E. Turtle, Pesticides Specialist, Plant Protection Service, FAO,
    Rome, Italy (Joint Secretary)

    Dr G. Vettorazzi, Scientist, Food Additives, WHO, Geneva, Switzerland

    INTRODUCTION

    A Joint Meeting of the FAO Working Party of Experts on Pesticide
    Residues and the WHO Expert Committee on Pesticide Residues was held
    in Geneva from 24 November to 3 December 1975. The general
    considerations, including the principles adopted for the evaluations
    and a summary of the results of evaluations on a number of pesticide
    residues, appear in the publication "Report of the 1975 Joint Meeting
    of the FAO Working Party of Experts on Pesticide Residues and the WHO
    Expert Committee on Pesticide Residues".1 Additional information,
    including previously unpublished summaries of data considered by the
    Joint Meeting in arriving at recommendations for acceptable daily
    intakes, tolerances and methods of analysis, is to be found in this
    document.

    Many of the compounds considered at this meeting have been previously
    evaluated in earlier publications. If only a limited amount of
    additional information of these compounds has become available in the
    intervening years, only this latter information is summarized in the
    pertinent monograph, and reference is made to the previously published
    evaluation, which should also be consulted by the reader who wishes to
    obtain a complete evaluation of the compound. Such monograph addenda
    are indicated by an asterisk in the "Contents", p. iii. If a large
    amount of data has became available since the previously published
    evaluation, or if the compound was first considered by the Joint
    Meeting in 1975, the pertinent monograph is reproduced in its
    entirety.

    As much relevant information as possible has been included in the
    monographs. This has been obtained from the published literature
    wherever possible, but other sources of information have also been
    used. Early and complete publication of the results of research in
    this field is very important, particularly of that part which could
    form the basis for estimation of acceptable daily intakes and
    appropriate tolerances.

    Publication allows the research to be scrutinized and criticized by
    scientists from disciplines not necessarily represented at the
    meeting. Data contained in unpublished reports, because they may
    include more detail than published work, are often acceptable.
    However, such reports must be complete and nonconfidential and
    indicate authorship.

              

    1 Pesticide residues in food. Report of the 1975 Joint Meeting of the
    FAO Working Party of Experts on Pesticide Residues and the WHO Expert
    Committee on Pesticide Residues, Wld Hlth Org. techn, Rep, Ser.,
    No. [text missing]; FAO Plant Production and Protection Series, No. 1


    Two annexes have been included at the end of this series of
    monographs. Annex 1 is a reproduction of Annex I in the Report of the
    1975 Joint Meeting,1 and gives the recommendations concerning
    acceptable daily intakes and residue limits made at the 1975 Meeting.
    Annex 3 gives bibliographic references to all previous Reports and
    monographs and other publications of a general nature.


    NOTE TO THE READER

    Any comments on evaluation for acceptable daily intake should be
    addressed to:

         Food Additives Unit
         World Health Organization
         Geneva, Switzerland

    Any comments on residues in food and their evaluation should be
    addressed to:

         Plant Protection Service
         Plant Production and Protection Division
         Food and Agriculture Organization
         Rome, Italy






















    See Also:
       Toxicological Abbreviations