International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 39 (1986) (p. 81)
CAS No.: 140-88-5
Chem. Abstr. Name: 2-Propenoic acid, ethyl ester
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Ethyl acrylate has been produced commercially since the early
1930s. Occupational exposure occurs in the manufacture of ethyl
acrylate and in the manufacture and use of its emulsion polymers. It
is also used as a synthetic flavouring substance and fragrance
adjuvant in consumer products.
5.2 Experimental data
Ethyl acrylate was tested for carcinogenicity by gavage in mice
and rats. Dose-related increases in the incidence of squamous-cell
papillomas and carcinomas of the forestomach were observed in both
species. Ethyl acrylate was tested by inhalation in the same strains
of mice and rats; no treatment-related neoplastic lesion was observed.
No treatment-related tumour was observed following skin application of
ethyl acrylate for lifespan to male mice.
In one experiment in rats, oral administration of ethyl acrylate
produced signs of embryotoxicity and foetotoxicity at mildly
maternally toxic doses but did not increase foetal malformation. It
was not embryotoxic, foetotoxic or teratogenic to rats at an airborne
concentration that produced slight maternal toxicity.
Ethyl acrylate was not mutagenic to Salmonella typhimurium in the
presence or absence of an exogenous metabolic system, nor was it
mutagenic to Drosophila melanogaster. It induced chromosomal
aberrations in Chinese hamster lung cells in vitro and micronuclei in
the bone marrow of mice treated in vivo.
5.3 Human data
No data were available to evaluate the reproductive effects or
prenatal toxicity of ethyl acrylate to humans.
No case report or epidemiological study was available to evaluate
the carcinogenicity of ethyl acrylate to humans.
There is sufficient evidence for the carcinogenicity of ethyl
acrylate in experimental animals.
No data on humans were available.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 19 (1979)
Subsequent evaluation: Vol. 71 (1999)
- Acrylic acid, ethyl ester
- Carboset 511
- CE 245
- Ethyl propenoate
- Ethyl 2-propenoate
- Latol 28-tall oil fatty acid
Last updated: 13 April 1999