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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

ACRYLIC ACID AND ACRYLATES

VOL.: 19 (1979) (p. 47)

Acrylic acid
CAS No.: 79-10-7
Chem. Abstr. Name: 2-Propenoic acid

Methyl acrylate
CAS No.: 96-33-3
Chem. Abstr. Name: 2-Propenoic acid methyl ester

Ethyl acrylate
CAS No.: 140-88-5
Chem. Abstr. Name: 2-Propenoic acid ethyl ester

Polyacrylic acid
CAS No.: 9003-01-4
Chem. Abstr. Name: 2-Propenoic acid homopolymer

5. Summary of Data Reported and Evaluation

5.1 Experimental data

No carcinogenicity or mutagenicity data on acrylic acid, methyl acrylate or polyacrylic acid were available to the Working Group.

Ethyl acrylate was tested in rats by oral administration; the reporting of the experiment was considered inadequate by the Working Group. No mutagenicity data on ethyl acrylate were available to the Working Group.

Acrylic acid is embryotoxic and teratogenic.

5.2 Human data

No case reports or epidemiological studies relating to the carcinogenicity of acrylic acid, methyl acrylate, ethyl acrylate or polyacrylic acid were available to the Working Group.

Acrylic acid is used primarily for the production of acrylates and polymers, and human exposure may be expected to occur. The use of methyl acrylate, ethyl acrylate and polyacrylic acid in a variety of textile, surface coating and other applications suggests other occupational exposures. Because methyl and ethyl acrylate as well as polyacrylic acid components are permitted in some countries for use in contact with foods, the general population may be exposed; in addition, polyacrylic acid sodium salt has been used as a food additive in one country.

5.3 Evaluation

The data available to the Working Group do not permit an evaluation of the carcinogenicity to humans of acrylic acid, methyl acrylate, ethyl acrylate or polyacrylic acid.

The Working Group noted the absence of data on carcinogenicity and mutagenicity for this group of substances and considered that suitable experiments should be undertaken. Even in the absence of such data in animals, because of the substantial production of these compounds and products containing them as well as the diversity of end-applications, research should be undertaken to identify exposed groups, to measure exposure levels and to conduct the appropriate epidemiological studies.

Subsequent evaluations: Vol 39 (1986) (Methyl acrylate, ethyl acrylate); Suppl. 7 (1987) (Ethyl acrylate, p. 63: Group 2B) (Methyl acrylate, p. 66: Group 3) (Polyacrylic acid, p. 70: Group 3); Vol 71 (1999) (Acrylic acid); (Ethyl acrylate); (Methyl acrylate)

For definition of Groups, see Preamble Evaluation.

Synonyms for Acrylic acid

Synonyms for Methyl acrylate

Synonyms for Ethyl acrylate

Synonyms for Polyacrylic acid


Last updated: 13 April 1999






















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       Toxicological Abbreviations