ICSC 0631 - AMITROLE

AMITROLE	ICSC: 0631 (June 2011)
1,2,4-Triazol-3-ylamine 3-Amino-1H-1,2,4-triazole Aminotriazole

CAS #: 61-82-5

UN #: 3077

EC Number: 200-521-5

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Combustible if powdered. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Use water spray, foam, powder, carbon dioxide.

STRICT HYGIENE!
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation		Avoid inhalation of dust and aerosol.	Fresh air, rest.
Skin	Redness.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes	Redness. Pain.	Wear face shield or eye protection in combination with breathing protection if powder.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion		Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable, plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Causes mild skin irritation Suspected of damaging fertility or the unborn child Causes damage to the thyroid through prolonged or repeated exposure Toxic to aquatic life with long lasting effects Transportation UN Classification UN Hazard Class: 9; UN Pack Group: III
STORAGE
Store in an area without drain or sewer access. Separated from strong acids, strong oxidants, acid anhydrides and acid chlorides. Do NOT store or transport in containers made from iron, aluminium or copper and its alloys. Separated from food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs.

AMITROLE

ICSC: 0631

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance ODOURLESS COLOURLESS CRYSTALS. Physical dangers Dust explosion possible if in powder or granular form, mixed with air. Chemical dangers Decomposes on heating and on burning. This produces toxic fumes of nitrogen oxides. The substance is a weak base. Reacts violently with strong acids, strong oxidants, acid chlorides and acid anhydrides. This generates fire and explosion hazard.	Formula: C₂H₄N₄ Molecular mass: 84.1 Decomposes when heated Melting point: 159°C Solubility in water, g/l at 25°C: 280 Octanol/water partition coefficient as log Pow: -0.97 Relative density (water = 1): 1.14 (20°C) Relative vapour density (air = 1): 2.9 Vapour pressure, kPa at 20°C: (negligible)

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
ODOURLESS COLOURLESS CRYSTALS.

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air.

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes of nitrogen oxides. The substance is a weak base. Reacts violently with strong acids, strong oxidants, acid chlorides and acid anhydrides. This generates fire and explosion hazard.

Formula: C₂H₄N₄
Molecular mass: 84.1
Decomposes when heated
Melting point: 159°C
Solubility in water, g/l at 25°C: 280
Octanol/water partition coefficient as log Pow: -0.97
Relative density (water = 1): 1.14 (20°C)
Relative vapour density (air = 1): 2.9
Vapour pressure, kPa at 20°C: (negligible)

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body by inhalation of its aerosol. Effects of short-term exposure The substance is mildly irritating to the eyes and skin.	Inhalation risk A nuisance-causing concentration of airborne particles can be reached on spraying. Effects of long-term or repeated exposure Tumours have been detected in experimental animals but may not be relevant to humans.

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol.

Effects of short-term exposure
The substance is mildly irritating to the eyes and skin.

Inhalation risk
A nuisance-causing concentration of airborne particles can be reached on spraying.

Effects of long-term or repeated exposure
Tumours have been detected in experimental animals but may not be relevant to humans.

OCCUPATIONAL EXPOSURE LIMITS
TLV: 0.2 mg/m³, as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans). MAK: (inhalable fraction): 0.2 mg/m³; peak limitation category: II(8); skin absorption (H); carcinogen category: 4; pregnancy risk group: C. EU-OEL: 0.2 mg/m³ as TWA

ENVIRONMENT
The substance is toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

NOTES
Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken. Do NOT take working clothes home.

ADDITIONAL INFORMATION

EC Classification
Symbol: Xn, N; R: 48/22-63-51/53; S: (2)-13-36/37-61

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    See Also:
       Toxicological Abbreviations
       Amitrole (EHC 158, 1994)
       Amitrole (HSG 85, 1994)
       Amitrole (WHO Pesticide Residues Series 4)
       Amitrole (Pesticide residues in food: 1977 evaluations)
       Amitrole (Pesticide residues in food: 1993 evaluations Part II Toxicology)
       Amitrole (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental)
       Amitrole  (IARC Summary & Evaluation, Supplement7, 1987)
       Amitrole  (IARC Summary & Evaluation, Volume 7, 1974)
       Amitrole  (IARC Summary & Evaluation, Volume 41, 1986)
       Amitrole  (IARC Summary & Evaluation, Volume 79, 2001)