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    FAO PLANT PRODUCTION AND PROTECTION PAPER 15 Sup.

    Pesticide Residues In Food:
    1978 Evaluations

    The Monographs

    Data And Recommendations
    Of The Joint Meeting
    Of The
    FAO Panel Of Experts On Pesticide Residues And The Environment
    And The
    WHO Expert Group On Pesticide Residues,
    Rome 27 Novembre-6 December 1978

    FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS
    Rome 1979

    The designation employed and the presentation of material in this
    publication do not imply the expression of any opinion whatsoever on
    the part of the Food and Agriculture Organization of the United
    Nations concerning the legal status of any country, territory, city of
    area or of its authorities, or concerning the delimitation of its
    frontiers or boundaries.

    M-84
    ISBN 92-5-100828-0

    The copyright in this book is vested in the Food and Agriculture
    Organization of the United Nations. The book may not be reproduced, in
    whole or in part, by any method or process, without written permission
    from the copyright holder. Applications for such permission, with the
    statement of the purpose and extent of the reproduction desired,
    should be addressed to the Director, Publications Division, Food and
    Agriculture Organization of the United Nations, Via delle Terme di
    Caracalla, 00100 Rome, Italy.

    (C) FAO 1979

    This document contains summaries of the data considered by the Joint
    Meeting of the FAO Panel of Experts on Pesticide Residues and the
    Environment and the WHO Expert Group on Pesticide Residues, which met
    in Rome, 27 November - 6 December, 1978, together with the
    recommendations made. A Report of the 1978 Joint Meeting, which
    outlines the principles on which the evaluations were carried out and
    summaries the recommendations made, has also been published.*





            
    * Pesticide Residues in Food: Report of the 1978 Joint Meeting of the
    FAO Panel of Experts on Pesticide Residues and the Environment and the
    WHO Export Group on Pesticide Residues, FAO Plant Production and
    Protection Series No. 15, 1979.

    CONTENTS

    List of attendees

    Introduction

    The Monographs

    (When the consideration or issues concerning a compound is fully
    covered by a statement appearing in the Report of the Meeting, the
    present volume only provides a reference to the relevant section of
    the Report).

    Acephate* (See Report section 3.7)

    Aminocarb

    Benomyl* (See Report section 3.3)

    Bromophos* (See Report section 3.7)

    Bromophos-ethyl* (See Report section 3.7)

    Bromopropylate* (See Report section 3.7)

    sec-BUTYLAMINE*

    Captan*

    Carbendazim*

    Cartap*

    Chlordane* (See Report section 3.2)

    Chlordimeform*

    Chlormequat* (See Report section 3.7)

    Chlorothalanil*

    Coumaphos*

    Cyanofenphos* (See Report section 4.16)

    Cyhexatin*

    DDT* (See Report section 3.5)

    Dialifos* (See Report section 3.7)

    Dimethoate* (See Report section 3.4)

    Diphenylamine* (See Report section 4.21)

    Diquat*

    Disulfoton*

    Endosulfan* (See Report section 3.7)

    Ethephon

    Ethiofencarb*

    Fenamiphos*

    Fenthion*

    Formothion* (See Report section 3.4)

    Guazatine

    HCH* (See Report section 3.6)

    Heptachlor* (See Report section 3.2)

    Hexachlorobenzene* (See Report section 4.33)

    Leptophos*

    Lindane*

    Methomyl*

    Omethoate*

    Paraquat*

    Parathion-methyl*

    Phosmet*

    Pirimicarb*

    Propargite*

    Propoxur* (See Report section 3.7)

    Quintozene* (See Report section 4.44)

    Tecnazene*

    Thiofanox (See Report section 4.46)

    Thiophanate-methyl* (See Report section 3.3)

    Trichlorfon*

    Triforine*

    Vinclozolin (See Report section 3.50)

    ANNEX 1 - Table of Acceptable Daily Intakes, Residue Limits and
    Guideline Levels Proposed at 1978 Meeting.

    ANNEX 2 - References to Previous FAO and WHO Documentation.


                

    * Addendum to previously published monograph.
    

    1978 JOINT MEETING OF THE FAO PANEL OF EXPERTS ON PESTICIDE RESIDUES
    AND ENVIRONMENT AND THE WHO EXPERT GROUP ON PESTICIDE RESIDUES

    Rome 27 November - 6 December 1978

    Members of the FAO Panel of Experts on Pesticide Residues and the
    Environment

    Dr. D.C. Abbott,    Deputy Director (Customer Services), Laboratory of
                        the Government Chemist, Cornwall House, Stamford
                        Street, London SE1 9NQ, England, U.K.

    Mr. A. Ambrus,      Department Head, Plant Protection and
                        Agrochemistry Centre, H-1502 Budapest, P.O.B. 127,
                        Hungary

    Dr. A.F.H. Besemer, Head, Pesticide Division, Plant Protection
                        Service, 15 Geertjesweg, Wageningen, The
                        Netherlands (Chairman)

    Dr. K.R. Hill,      Chief, Analytical Chemistry Laboratory, U.S.
                        Department of Agriculture, Agricultural
                        Environmental Quality Institute, Room 114, Bld.
                        306, Beltssville, Maryland 20705, U.S.A.

    Dr. E.D. Magallona, Assistant Professor and Head, Pesticide Residue
                        and Toxicology Laboratory, University of the
                        Philippines at Los Baños, College, Languna 3720,
                        Republic of the Philippines

    Mr. J.T. Snelson,   Pesticides Co-ordinator, Department of Primary
                        Industry, Canberra., A.C.T. 2600, Australia
                        (Rapporteur)

    Observers Invited by FAO

    Dr. F-W. Kopisch-Obuch, German Agency for Technical Cooperation Ltd.
                        (GTZ), Pesticide Residue Project D-6100 Darmstadt,
                        Rheinstrasse 91, Postfach 4001, Federal Republic
                        of Germany

    Mr. A.J. Pieters,   Chairman, Codex Committee on Pesticide Residues,
                        Public Health Inspector, Ministry of Public Health
                        and Environmental Hygiene, Dokter Reijersstraat
                        12, Leidschendam, Netherlands

    Members of the WHO Expert Group on Pesticide Residues

    Dr. E.A. Bababunmi, Associate Professor (Reader), Department of
                        Biochemistry, University of Ibadan, School of
                        Medicine, Ibadan, Nigeria (Rapporteur)

    Mr. D.J. Clegg,     Head, Pesticide Section, Toxicological Evaluation
                        Division, Feeds Directorate, Health Protection
                        Branch, Department of National Health and Welfare,
                        Tunney's Pasture, Ottawa, K1A 0L2, Canada
                        (Vice-Chairman)

    Prof. Dr. P. Engst, Central Institute for Nutrition, Academy of
                        Sciences, (1505) Bergholz-Rehbrücke/DDR, German
                        Democratic Republic

    Dr. S.D. Murphy,    Professor of Toxicology, University of Texas
                        Health Science Center at Houston, Medical School,
                        P.O. Box 20708, Houston, Texas 77025, U.S.A.

    Dr. G.H. Sanai,     Professor Department of Occupational and
                        Environmental Health, School of Public Health,
                        University of Teheran, P.O. Box 1310, Teheran,
                        Iran

    Dr. B. Terracini,   Professor of Cancer Epidemiology, University of
                        Torino, Università di Torino, Via Santena 7, 10126
                        Torino, Italy

    Secretariat

    Dr. R.L. Baron,     Health Effects Research Laboratory, Environmental
                        Protection Agency Research Triangle Park, No.
                        Carolina 27711, U.S.A. (Temporary Adviser)

    Mr. J.A.R. Bates,   Ministry of Agriculture, Fisheries and Food, Plant
                        Pathology Laboratory, Hatching Green, Harpenden,
                        Herts. AL5 2BD, England

    Dr. L. Brader,      Chief, Plant Protection Service, FAO, Rome, Italy

    Dr. C.L. Galli,     Institute of Pharmacology and Pharmacognosy,
                        School of Pharmacy, University of Milan, Via A.
                        del Sarto 21, 20129 Milano, Italy (Temporary
                        Adviser)

    Dr. A. Hassan,      Technical Officer, Chemical Residue and Pollution
                        Section, Joint FAO/IAEA. Division, P.O. Box 590,
                        1011 Vienna, Austria

    Dr. M. van Logten,  Head, Laboratory for General Toxicology, National
                        Institute of Public Health, Bilthoven, Netherlands
                        (Temporary Adviser)

    Mr. A.F. Machin,    Senior Research Officer, Central Veterinary
                        Laboratory, Ministry of Agriculture Fisheries and
                        Food, New Haw, Weybridge, Surrey KT15 3NB England,
                        (Consultant)

    Dr. G. Schlatter,   Professor of Toxicology, Institute of Toxicology,
                        ETH and University of Zürich, CH-8603
                        Schwerzenbach (Zürich), Switzerland (Temporary
                        Adviser)

    Dr. E.E. Turtle,    Pesticides Specialist, Plant Protection Service,
                        FAO, Rome, Italy (Joint Secretary)

    Dr. G. Vettorazzi,  Scientist, Food Safety, Environmental Health
                        Criteria and Standards, World Health Organization,
                        Avenue Appia 1211, Geneva 27, Switzerland (Joint
                        Secretary)

    INTRODUCTION

         The report of the Joint Meeting of the FAO Panel of Experts on
    Pesticide Residues and the Environment and the WHO Expert Group on
    Pesticide Residues held in Rome from 27 November to 6 December 1978
    provides information on the general principles followed and the
    considerations of the meeting. It also contains a summary of the
    evaluations made on residues in foods of the various pesticides
    considered at the session. The present document contains summaries of
    the data considered at the session. The present document contains
    summaries of the data considered by the Meeting together with the
    recommendations made.

         As much relevant information as possible has been included in the
    monographs. This has been obtained from the published literature
    wherever possible, but other sources of information have also been
    used. Early and complete publications of the results of research in
    this field are very important, particularly of these parts which can
    form the basis for estimation of acceptable daily intakes and
    appropriate residue levels. Publication allows the research to be
    scrutinized and criticized by scientists from disciplines not
    necessarily represented at the meeting. Data contained in unpublished
    reports is less satisfactory and, when considered, must be complete
    and nonconfidential and indicate authorship.

         Some of the compounds considered at this meeting have been
    previously evaluated and reports on in earlier publications. If only a
    limited amount of additional information of these compounds has become
    available at this meeting, only this latter information is summarized
    in the pertinent monograph, and reference is made to the previously
    published evaluation, which should also be consulted by the reader who
    wishes to obtain a more complete evaluation of the compound. Such
    monograph addenda are indicated by an asterisk in the "Contents"
    sheet.

         Annex 1 to this volume of monographs gives a summary of the
    recommendations concerning acceptable daily intakes, residue limits
    and guideline levels made at the 1978 Meeting. It has already appeared
    as an Annex to the Report of the Meeting.

    NOTE TO THE READER

         Any comments on evaluation for acceptable daily intake should be
    addressed to:

                        Food Safety Unit
                        World Health Organization
                        Geneva, Switzerland

         Any comments on residues in food and their evaluation should be
    addressed to:

                        Plant Protection Service
                        Plant Production and Protection Division
                        Food and Agriculture Organization
                        Rome, Italy





















    See Also:
       Toxicological Abbreviations