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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CHRYSENE

VOL.: 32 (1983) (p. 247)

CAS No.: 218-01-9

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Chrysene was tested for carcinogenicity in several studies by skin application to mice and produced skin tumours; in one study, an enhancing effect was observed when chrysene was tested simultaneously with n-dodecane. Chrysene was also tested in the mouse-skin initiation-promotion assay and was active as an initiator. Local tumours were observed following its subcutaneous injection in mice. Perinatal administration of chrysene to mice by subcutaneous or intraperitoneal injection increased the incidences of liver tumours.

No relevant data on the teratogenicity of this chemical were available.

Chrysene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. It did not induce mitotic recombination in yeast, unscheduled DNA synthesis in primary rat hepatocytes, or mutations in Chinese hamster V79 cells. However, in one study each in mice and hamsters it induced sister chromatid exchange and chromosomal aberrations, respectively. It was positive in one of two reported studies of morphological transformation in mammalian cells.

There is limited evidence that chrysene is active in short-term tests.

5.2 Human data

Chrysene is present as a major component of the total content of polynuclear aromatic compounds in the environment. Human exposure to chrysene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

There is limited evidence that chrysene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 3 (1973)

Subsequent evaluation: Suppl. 7 (1987) (p. 60: Group 3)

Synonyms


Last updated: 17 April 1998






















    See Also:
       Toxicological Abbreviations
       Chrysene (ICSC)