International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 1 (1972) (p. 61)

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

The carcinogenicity of chloroform has been investigated only in mice in experiments involving a small number of animals at risk. Nevertheless among these the frequency of liver tumours was high. There is no evidence of carcinogenicity for organs other than the liver, but the experiments were shorter than the life-span of the animals. An experiment involving single or a few exposures of newborn mice gave negative results. An assessment of the carcinogenicity of chloroform awaits further experimental evidence.

5.2 Human carcinogenicity data

Chloroform entails several sources of exposure for humans. No long-term follow-up studies in men exposed to chloroform have been reported.

Subsequent evaluations: Vol. 20 (1979); Suppl. 7 (1987); Vol. 73 (1999)

Last updated: 30 September 1999

    See Also:
       Toxicological Abbreviations
       Chloroform (EHC 163, 1994)
       Chloroform (HSG 87, 1994)
       Chloroform (ICSC)
       Chloroform (WHO Food Additives Series 14)
       CHLOROFORM (JECFA Evaluation)
       Chloroform (PIM 121)
       Chloroform (CICADS 58, 2004)
       Chloroform  (IARC Summary & Evaluation, Volume 73, 1999)