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    FAO Nutrition Meetings
    Resort Series No. 44A
    WHO/Food Add./68.33




    TOXICOLOGICAL EVALUATION OF SOME
    FLAVOURING SUBSTANCES AND
    NON-NUTRITIVE SWEETENING AGENTS





    Geneva, 21-28 August 1967



    The Eleventh Report of the Joint FAO/WHO Expert Committee on Food
    Additives is published as FAO Nutrition Meetings Report Series,
    1967, No. 44; Wld Hlth Org. techn. Rep. Ser., 1968, 383. This
    Report contains general considerations, including the principles
    adopted for the evaluation, and a summary of the results of the
    evaluations of a number of food additives. Additional information,
    such as biological data and a toxicological evaluation, considered at
    that meeting, is to be found in this document.


    Food and Agriculture Organization of the United Nations
    World Health Organization
    1967


    NONANAL

    Synonyms                 Pelargonic aldehyde; Aldehyde C-9

    Chemical name            Nonanal

    Empirical formula        C9H18O

    Structural formula       CH3(CH2)7CHO

    Molecular weight         142.24

    Definition               Nonanal contains not less than 92 per cent.
                             C9H18O.

    Description              A colourless to light yellow liquid having a
                             strong fatty odour which develops an orange
                             and rose character on being diluted.

    Biological Data

    Biochemical aspects

         No information available.

    Acute toxicity

         None available.

    Short-term studies

         Rat. In a 12-week feeding study on 15 males and 15 females,
    using mixed aldehydes, no adverse effects were seen at 25.6 mg/kg
    body-weight/day (Oser, 1967).

    Long-term studies

         None available.

    Comments

         The evaluation is based on the short-term studies. Metabolic
    studies are needed.

    EVALUATION

    Estimate of acceptable daily intake for man

                                  mg/kg body-weight

         Conditional acceptance        0-0.1

    Further work required

         Biochemical studies in animals and man.

    REFERENCES

    Oser, B. L. (1967) Unpublished report
    


    See Also:
       Toxicological Abbreviations
       Nonanal (WHO Food Additives Series 14)
       NONANAL (JECFA Evaluation)