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    FAO/PL:1969/M/17/1

    WHO/FOOD ADD./70.38

    1969 EVALUATIONS OF SOME PESTICIDE RESIDUES IN FOOD

    THE MONOGRAPHS

    Issued jointly by FAO and WHO

    The content of this document is the result of the deliberations of the
    Joint Meeting of the FAO Working Party of Experts and the WHO Expert
    Group on Pesticide Residues, which met in Rome, 8 - 15 December 1969.

    FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS

    WORLD HEALTH ORGANIZATION

    Rome, 1970

    This document contains summaries of data considered by the Joint
    Meeting of the FAO Working Party of Experts and the WHO Expert Group
    on Pesticide Residues in arriving at recommendations for acceptable
    daily intakes, tolerances and methods of analysis.

    A summary Report of the 1969 Joint Meeting* has also been published
    which contains general considerations, including the principles
    adopted for the evaluations and a summary of the results of
    evaluations of a number of pesticide residues.


                 
    * Pesticide residues in food. Report of the 1969 joint meeting of the
    FAO working party of experts on pesticide residues and the WHO expert
    group on pesticide residues, FAO Agricultural Studies, No. 84 WHO
    Technical Report Series, No. 458

    CONTENTS

    List of Attendees

    Introduction 

    Note to the reader

    The Monographs

    Binapacryl

    Bromide Ion*

    Captafol

    Captan

    Carbaryl*

    Chlordane*

    DDT*

    Dichlofluanid

    Dichlorvos*

    Dieldrin*

    Dinocap

    Diphenylamine

    Ethion*

    Ethoxyquin

    Fenitrothion

    Folpet

    Formothion

    Heptachlor*

    Hexachlorobenzene

    Hydrogen Phosphide*

    Lindane*

    Malathion*

    Parathion*

    2-Phenylphenol and its Sodium Salt

    Phosphamidon*

    Piperonyl Butoxide*

    Pyrethrins*

    Quintozene

    Thiometon

    Appendix I - Index to documentation and summary of recommendations
    concerning acceptable daily intakes, tolerances and limits at December
    1969

    Appendix II - References

    Appendix III - Glossary


                 
    * Addendum

    

    LIST OF ATTENDEES

    Members of the FAO Working Party of Experts on Pesticide Residues:

    Dr. D.C. Abbott, Head, Division of Pesticides and Toxic Gases,
    Laboratory of the Government Chemist, Cornwall House, Stamford Street,
    London, S.E.1, England

    Dr. M. Beroza, Investigation Leader (Chemist), US Department of
    Agriculture, Agriculture Research Centre, Beltsville, Maryland, USA

    Dr. H. Hurtig, Research Coordinator (Pesticides), Research Branch,
    Canada Department of Agriculture, Central Experimental Farm, Ottawa,
    Ontario, Canada (Chairman)

    Dr. A.H.M. Kirby, Head, Plant Protective Chemistry Section, East
    Malling Research Station, East Malling, Maidstone, Kent, England

    Dr. P. Koivistoinen, Director of Food Chemistry Division, University
    of Helsinki, Institute of Food Chemistry and Technology, Vikki,
    Helsinki 71, Finland

    Mr. J.T. Snelson, Pesticide Coordinator, Department of Primary
    Industry, Canberra ACT, Australia (Rapporteur)

    Members of the WHO Expert Group on Pesticide Residues:

    Professor F. Bär, Director, Division of Toxicology and Nutrition,
    Federal Ministry of Health, Bad Godesberg, Federal Republic of Germany

    Professor A. Bojanowska, Director, Department of Sanitary Toxicology,
    State Institute of Hygiene, Warsaw, Poland

    Professor F. Coulston, Director, Institute of Experimental Pathology
    and Toxicology, The Albany Medical College of Union University,
    Albany, N.Y., USA (Vice-Chairman)

    Dr. O.G. Fitzhugh, Toxicological Adviser, Division of Toxicological
    Evaluation, Bureau of Science, Food and Drug Administration,
    Washington, D.C., USA

    Dr. W.A. Mannell, Chief, Division of Toxicology, Bureau of Food
    Advisory Services, Food and Drug Directorate, Ottawa, Ontario, Canada

    Dr. E. Poulsen, Director, National Food Institute, Institute of
    Toxicology, Soborg, Denmark (Rapporteur)

    Professor R. Truhaut, Director, Toxicological Research Centre, Faculty
    of Pharmacy of the University of Paris, Paris, France

    Dr. H.G. Verschuuren, Head, Department of Biological Toxicology,
    National Institute of Public Health, Utrecht, The Netherlands

    Secretariat:

    Dr. P.E. Berteau, Scientist, Food Additives, WHO

    Mr. A. Eisenberg, Food Standards Branch, FAO (Consultant)

    Dr. F.C. Lu, Chief, Food Additives, WHO (Joint Secretary)

    Dr. L. Tomatis, Chief, Unit of Chemical Carcinogenisis, International
    Agency for Research on Cancer, Lyon, France

    Dr. E.E. Turtle, Head, Chemistry Department, Infestation Control
    Laboratory, Ministry of Agriculture, Fisheries and Food, Tolworth,
    Surrey, England (Consultant)

    Dr. F.W. Whittemore, Chief, Crop Protection Branch, Plant Production
    and Protection Division, FAO (Joint Secretary)

    Dr. F.P.W. Winteringham, Head, Pesticide Residues and Pollution
    Section, Joint FAO/IAEA Division of Atomic Energy in Agriculture,
    Vienna

    INTRODUCTION

    A Joint Meeting of the FAO Working Party of Experts on Pesticide
    Residues and the WHO Expert Group on Pesticide Residues was held in
    Rome in December 1969. The general considerations, including the
    principles adopted for the evaluations and a summary of the results of
    evaluations on a number of pesticide residues will appear in a
    publication entitled "Report of the 1969 Joint Meeting of the FAO
    Working Party of Experts on Pesticide Residues and the WHO Expert
    Group on Pesticide Residues".* Additional information, including
    previously unpublished summaries of data considered by the Joint
    Meeting in arriving at recommendations for acceptable daily Intakes,
    tolerances and methods of analysis, is to be found in this document.

    Many of the compounds considered at this meeting have been previously
    evaluated in earlier publications. If only a limited amount of
    additional data on these compounds have become available in the
    intervening years, only this latter data are summarized in the
    pertinent monograph and reference is made to the previously published
    evaluation which should also be consulted by the reader who wishes to
    obtain a complete evaluation of the compound. Such monograph addenda
    are indicated by an asterisk in the 'Contents', p. (iii). If a large
    amount of data has become available since the previously published
    evaluation, or if the compound was first considered by the Joint
    Meeting in 1969, the pertinent monograph is reproduced in its
    entirety.

    As much relevant information as possible has been included in the
    monographs. Wherever possible this has been obtained from the
    published literature, but other sources of information have also been
    used. Early and complete publication of the results of research in
    this field is very important, particularly of that part which could
    form the basis for estimation of acceptable daily intakes and
    appropriate tolerances.

    Publication allows the research to be scrutinized and criticized by
    scientists from disciplines not necessarily represented at the
    meeting. Data contained in unpublished reports, because they may
    include more detail than published work, are often acceptable.
    However, such reports must be complete and non-confidential and
    indicate authorship.

    Three appendices have been included at the and of this series of
    monographs. Appendix I is a reproduction of Appendix I in the Report
    of the 1969 Joint Meeting* and gives the source of all the previous

                  
    * Pesticide residues in food. Report of the 1969 Joint Meeting of
    the FAO Working Party of Experts on Pesticide Residues and the WHO
    Expert Group on Pesticide Residues, FAO Agricultural Studies, No. 84,
    WHO Technical Report Series, No. 458.

    monographs of various compounds and Appendix II gives relevant
    bibliographic data. Appendix III comprises a definition of terms, most
    of which were included in the Report of the 1968 Joint Meeting.+ Two
    additional terms, namely "Conditional Acceptable Daily Intake" and
    "Tentative Negligible Daily Intake" are also defined in this Appendix.

    NOTE TO THE READER

    Any comments on residues in food and their evaluation should be
    addressed to:

    Plant Protection Service
    Plant Production and Protection Division
    Food and Agriculture Organization
    Rome, Italy

    Any comments on evaluations for acceptable daily intakes should be
    addressed to:

    Food Additives Unit
    World Health Organization
    Geneva, Switzerland



                  
    + Report of the 1968 Joint Meeting of the FAO Working Party of
    Experts on Pesticide Residues and the WHO Expert Committee on
    Pesticide Residues, FAO Agricultural Studies, No. 78, WHO Technical
    Report Series, No. 417.





















    See Also:
       Toxicological Abbreviations