IPCS INCHEM Home
KETOCONAZOLE
ICSC: 1700
Peer-Review Status: 02.04.2009 Validated
Ketoconazol 
CAS #: 65277-42-1 RTECS #: TK7912300
UN #: 2811
EC #: 613-283-00-6
EINECS #: 265-667-4
    Formula: C26H28Cl2N4O4
Molecular mass: 531.5

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Not combustible.    In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE   STRICT HYGIENE!   
Inhalation Cough.  Use local exhaust or breathing protection.  Fresh air, rest. 
Skin Redness.  Protective gloves.  Rinse and then wash skin with water and soap. 
Eyes   Wear safety goggles.  Rinse with plenty of water (remove contact lenses if easily possible). 
Ingestion Nausea. Headache. Dizziness. Vomiting. Diarrhoea.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T, N; R: 60-25-48/22-50/53; S: 53-45-60-61; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Toxic if swallowed
May damage fertility or the unborn child
Causes damage to endocrine system through prolonged or repeated exposure if swallowed
Very toxic to aquatic life 
skull;toxiccancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
  Provision to contain effluent from fire extinguishing. Well closed. Separated from food and feedstuffs. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS CRYSTALS OR POWDER. 

Physical dangers
No data. 

Chemical dangers
No data. 

Occupational exposure limits
TLV not established.
MAK (not established):. 

Routes of exposure
The substance can be absorbed into the body by ingestion. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
 

Effects of long-term or repeated exposure
The substance may have effects on the endocrine system and liver. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 148-152°C
Solubility in water: none
Vapour pressure, Pa at 25°C: (negligible)
Octanol/water partition coefficient as log Pow: 4.35  
The substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Synonyms for this substance are: (+)-cis-1-Acetyl-4-4-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenylpiperazine and 1-4-4-(2SR,4RS)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenylpiperazin-1-ylethanone. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations