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3-CHLORO-1,2-PROPANEDIOL (RACEMIC MIXTURE)
ICSC: 1664
Peer-Review Status: 01.04.2009 Validated
alpha-Chlorohydrin
Glycerol alpha-monochlorohydrin
Chlorhydrin
3-Chloro-1,2-dihydroxypropane 
CAS #: 96-24-2 RTECS #: TY4025000
UN #: 2689
EINECS #: 202-492-4
    Formula: C3H7ClO2 / HOCH2CHOHCH2Cl
Molecular mass: 110.5

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames.  Use alcohol-resistant foam, dry powder, carbon dioxide. 
EXPLOSION Risk of explosion on contact with strong oxidants.     
 
EXPOSURE   PREVENT GENERATION OF MISTS!   
Inhalation Cough. Sore throat. Further see Ingestion.  Avoid inhalation of mist.  Fresh air, rest. Refer for medical attention. 
Skin See Ingestion.  Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear safety goggles.  Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion Cough. Sore throat. Headache. Dizziness. Drowsiness.  Do not eat, drink, or smoke during work.  Rinse mouth. Give one or two glasses of water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Fatal if inhaled
Toxic if swallowed
Harmful in contact with skin
Causes serious eye irritation
Suspected of causing cancer
Suspected of damaging fertility or the unborn child
Causes damage to central nervous system if swallowed
May cause respiratory irritation
Causes damage to the kidneys through prolonged or repeated exposure if swallowed 
skull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
  Dry. Well closed. Separated from strong oxidants and food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-PALE-YELLOW HYGROSCOPIC LIQUID. 

Physical dangers
No data. 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including hydrogen chloride (see ICSC 0163). Reacts with strong oxidants. This generates fire and explosion hazard. 

Occupational exposure limits
TLV not established.
MAK (2b (not established but data is available)): (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. 

Effects of long-term or repeated exposure
The substance may have effects on the kidneys. This may result in kidney impairment. Tumours have been detected in experimental animals but may not be relevant to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 213°C
Boiling point at 1.9kPa: 114-120°C
Melting point: -40°C
Relative density (water = 1): 1.32
Solubility in water: miscible
Vapour pressure, Pa at 20°C: 27
Relative vapour density (air = 1): 3.8
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 113°C c.c.
Octanol/water partition coefficient as log Pow: -0.53 (estimated)
Viscosity: 182 mm²/s at 20°C 
 

NOTES
Health effects of exposure to the substance have not been investigated adequately.
CAS numbers for optical isomers are 57090-45-6 for the R(-) isomer and 60827-45-4 for the S(+) isomer. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
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    See Also:
       Toxicological Abbreviations