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DIAZOMETHANEICSC: 1256
March 1995
CAS #: 334-88-3Azimethylene
Diazirine
EINECS #: 206-382-7

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Extremely flammable. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.  Gas/air mixtures are explosive.  NO open flames, NO sparks and NO smoking.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT expose to friction or shock. Prevent build-up of electrostatic charges (e.g., by grounding).  Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide.  Combat fire from a sheltered position. 

 AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Headache. Laboured breathing. Shortness of breath. Sore throat. Vomiting. Malaise. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Burning sensation. Pain. Frostbite.  Cold-insulating gloves.  ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention . Wear protective gloves when administering first aid. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.   

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Ventilation. Personal protection: complete protective clothing including self-contained breathing apparatus. 

According to UN GHS Criteria

 

Transportation
UN Classification
 

STORAGE
Solutions of diazomethane should not be stored. See Notes. 
PACKAGING
 
DIAZOMETHANE ICSC: 1256
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
YELLOW GAS. 

Physical dangers
The gas is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
May decompose explosively on shock, friction or concussion. May explode on heating at 100°C or on contact with rough surfaces or if impurities or solids are present in the undiluted liquid or in the concentrated solutions or under high intensity lighting. Contact with alkali metals and calcium sulfate causes explosion. 

Formula: CH2N2
Molecular mass: 42.04
Boiling point: -23°C
Melting point: -145°C
Relative density (water = 1): 1.45
Solubility in water: reaction
Relative vapour density (air = 1): 1.4
Flash point: Flammable gas
Auto-ignition temperature: 100°C (explosion) 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation. 

Effects of short-term exposure
The substance is very corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Inhalation of the vapour may cause asthmatic reactions. See Notes. The liquid may cause frostbite. Exposure above the OEL could cause death. Medical observation is indicated. 

Inhalation risk
A harmful concentration of this gas in the air will be reached very quickly on loss of containment. 

Effects of long-term or repeated exposure
Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans. 


Occupational exposure limits
TLV: 0.2 ppm as TWA; A2 (suspected human carcinogen).
MAK: carcinogen category: 2 

ENVIRONMENT
 

NOTES
Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
The relation between odour and the occupational exposure limit cannot be indicated.
The recommendations on this Card also apply to concentrated solutions of diazomethane. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T; R: 45; S: 53-45 

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    See Also:
       Toxicological Abbreviations
       Diazomethane (IARC Summary & Evaluation, Volume 7, 1974)