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DIAZOMETHANE
ICSC: 1256
Peer-Review Status: 15.03.1995 Validated
Azimethylene
Diazirine 
CAS #: 334-88-3 RTECS #: PA7000000
EC #: 006-068-00-8
EINECS #: 206-382-7
    Formula: CH2N2
Molecular mass: 42.04

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Extremely flammable. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames, NO sparks and NO smoking.  Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out. In other cases extinguish with powder, carbon dioxide. 
EXPLOSION Gas/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT expose to friction or shock. Prevent build-up of electrostatic charges (e.g., by grounding).  Combat fire from a sheltered position. 
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Headache. Laboured breathing. Shortness of breath. Sore throat. Vomiting. Malaise. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Burning sensation. Pain. Frostbite.  Cold-insulating gloves.  ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Refer for medical attention . Wear protective gloves when administering first aid. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.   

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Ventilation. Personal protection: complete protective clothing including self-contained breathing apparatus.   
EC Classification
Symbol: T; R: 45; S: 53-45 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Solutions of diazomethane should not be stored. See Notes. 

IMPORTANT DATA
Physical State; Appearance
YELLOW GAS. 

Physical dangers
The gas is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
May decompose explosively on shock, friction or concussion. May explode on heating at 100°C or on contact with rough surfaces or if impurities or solids are present in the undiluted liquid or in the concentrated solutions or under high intensity lighting. Contact with alkali metals and calcium sulfate causes explosion. 

Occupational exposure limits
TLV: 0.2ppm as TWA; A2 (suspected human carcinogen); (ACGIH 2008).
MAK: Carcinogen category: 2; (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation. 

Inhalation risk
A harmful concentration of this gas in the air will be reached very quickly on loss of containment. 

Effects of short-term exposure
The substance is very corrosive to the eyes, skin and respiratory tract. Inhalation of the vapour may cause lung oedema. Inhalation of the vapour may cause asthmatic reactions. See Notes. The liquid may cause frostbite. Exposure above the OEL could cause death. Medical observation is indicated. 

Effects of long-term or repeated exposure
Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: -23°C
Melting point: -145°C
Relative density (water = 1): 1.45
Solubility in water: reaction
Relative vapour density (air = 1): 1.4
Flash point: Flammable gas
Auto-ignition temperature: 100°C (explosion) 
 

NOTES
Because of its toxicity and its explosive nature, diazomethane is freshly prepared in situ and used in solution of ether or dioxane.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Immediate administration of an appropriate spray, by a doctor or a person authorized by him/her, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
The relation between odour and the occupational exposure limit cannot be indicated.
The recommendations on this Card also apply to concentrated solutions of diazomethane.
Card has been partly updated in April 2005.
See section Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Diazomethane (IARC Summary & Evaluation, Volume 7, 1974)