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PICLORAM
ICSC: 1246
Peer-Review Status: 08.06.2012 Validated
4-Amino-3,5,6-trichloro-2-pyridinecarboxylic acid
4-Amino-3,5,6-trichloropicolinic acid 
CAS #: 1918-02-1 RTECS #: TJ7525000
EINECS #: 217-636-1
    Formula: C6H3Cl3N2O2
Molecular mass: 241.5

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE      
Inhalation No acute symptoms expected.  Avoid inhalation of dust.  Fresh air, rest. 
Skin No acute symptoms expected.  Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes No acute symptoms expected.  Wear safety goggles.  Rinse with plenty of water (remove contact lenses if easily possible). 
Ingestion No acute symptoms expected.  Do not eat, drink, or smoke during work.  Rinse mouth. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.   
EC Classification
 
UN Classification
 
GHS Classification
Signal: Warning
Harmful if swallowed
May cause damage to liver through prolonged or repeated exposure
Harmful to aquatic life 
excl mark;warncancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
  Dry. Keep in a well-ventilated room. Separated from : see Chemical Dangers. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS CRYSTALS OR WHITE POWDER WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces nitrogen oxides (see ICSC 0067, ICSC 0930) and hydrogen chloride (see ICSC 0163). Reacts with strong acids, strong bases and strong oxidants. This generates fire and explosion hazard. 

Occupational exposure limits
TLV: 10mg/m³ as TWA; A4 (not classifiable as a human carcinogen); (ACGIH 2011).
MAK (not established): (DFG 2011).
EU OEL ( selected):. 

Routes of exposure
The substance can be absorbed into the body by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of short-term exposure
 

Effects of long-term or repeated exposure
The substance may have effects on the liver. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: No melting point; decomposes 190°C
Solubility in water, mg/l at 25°C: 430 (very poor)
Octanol/water partition coefficient as log Pow: 1.9
Vapour pressure: negligible 
The substance is harmful to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Picloram (IARC Summary & Evaluation, Volume 53, 1991)