IPCS INCHEM Home
CHROMIUM(VI) OXIDE
ICSC: 1194
Peer-Review Status: 27.10.2004 Validated
Chromic trioxide
Chromic acid
Chromic anhydride 
CAS #: 1333-82-0 RTECS #: GB6650000
UN #: 1463
EC #: 024-001-00-0
EINECS #: 215-607-8
    Formula: CrO3
Molecular mass: 100.0

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Not combustible but enhances combustion of other substances. Many reactions may cause fire or explosion.  NO contact with combustible substances or reducing agents.  NO water. In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Laboured breathing. Shortness of breath. Sore throat. Wheezing. Burning sensation. Symptoms may be delayed. See Notes.  Use closed system or ventilation.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Skin burns. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain. Severe deep burns.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Burning sensation. Shock or collapse.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Vacuum spilled material with specialist equipment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: O, T+, N; R: 45-46-9-24/25-26-35-42/43-48/23-62-50/53; S: 53-45-60-61; Note: E 
UN Classification
UN Hazard Class: 5.1; UN Subsidiary Risks: 8; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-51S1463.
NFPA Code: H3; F0; R1; OX. 
Separated from combustible substances, reducing agents, bases and food and feedstuffs. Dry. 

IMPORTANT DATA
Physical State; Appearance
ODOURLESS DARK RED DELIQUESCENT CRYSTALS, FLAKES OR GRANULAR POWDER. 

Physical dangers
No data. 

Chemical dangers
Decomposes above 250°C . This produces chromic oxide and oxygen. This increases fire hazard. The substance is a strong oxidant. It reacts violently with combustible and reducing materials. This generates fire and explosion hazard. The solution in water is a strong acid. It reacts violently with bases and is corrosive. 

Occupational exposure limits
TLV: 0.05mg/m³ as TWA; A1 (confirmed human carcinogen); BEI issued; (ACGIH 2004).
MAK: Carcinogen category: 2; Sensitization of skin (SH); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. Repeated or prolonged inhalation may cause nasal ulceration. This may result in perforation of the nasal septum. The substance may have effects on the kidneys. This may result in kidney impairment. This substance is carcinogenic to humans. May cause heritable genetic damage to human germ cells. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 250°C
Melting point: 197°C
Density: 2.7 g/cm³
Solubility in water: good 
The substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Rinse contaminated clothes (fire hazard) with plenty of water.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
Do NOT take working clothes home.
Depending on the degree of exposure, periodic medical examination is suggested. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations