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CHROMIUM(VI) OXIDE
ICSC: 1194
Peer-Review Status: 12.04.2013 Validated
Chromic trioxide
Chromic acid
Chromic anhydride 
CAS #: 1333-82-0 RTECS #: GB6650000
UN #: 1463
EC #: 024-001-00-0
EINECS #: 215-607-8
    Formula: CrO3
Molecular mass: 100.0

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Not combustible but enhances combustion of other substances. Many reactions may cause fire or explosion.  NO contact with combustible substances or reducing agents.  NO water. In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Burning sensation. Sore throat. Cough. Wheezing. Laboured breathing.  Use closed system or ventilation.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Pain. Skin burns.  Protective gloves. Protective clothing.  Remove contaminated clothes. First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention . 
Eyes Redness. Pain. Blurred vision. Severe burns.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Nausea. Vomiting. Abdominal pain. Burning sensation. Diarrhoea. Shock or collapse.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Do NOT absorb in saw-dust or other combustible absorbents.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: O, T+, N; R: 45-46-9-24/25-26-35-42/43-48/23-62-50/53; S: 53-45-60-61; Note: E 
UN Classification
UN Hazard Class: 5.1; UN Subsidiary Risks: 6.1 and 8; UN Pack Group: II 
GHS Classification
Signal: Danger
May intensify fire; oxidizer
Toxic if swallowed
Fatal in contact with skin or if inhaled
Causes severe skin burns and eye damage
May cause allergy or asthma symptoms or breathing difficulties if inhaled
May cause an allergic skin reaction
May cause genetic defects
May cause cancer
May damage fertility or the unborn child
Causes damage to the kidneys through prolonged or repeated exposure
Causes damage to the nose through prolonged or repeated exposure if inhaled
Very toxic to aquatic life with long lasting effects 
flam circleskull;toxiccorrcancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F0; R1; OX.  Provision to contain effluent from fire extinguishing. Separated from combustible substances, reducing agents, bases and food and feedstuffs. Well closed. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
ODOURLESS DARK RED DELIQUESCENT CRYSTALS, FLAKES OR GRANULAR POWDER. 

Physical dangers
No data. 

Chemical dangers
Decomposes above 250°C . This produces chromic oxide and oxygen. This increases fire hazard. The substance is a strong oxidant. It reacts violently with combustible and reducing materials. This generates fire and explosion hazard. The solution in water is a strong acid. It reacts violently with bases and is corrosive. 

Occupational exposure limits
TLV (as Cr): 0.05mg/m³ as TWA; A1 (confirmed human carcinogen); (ACGIH 2012).
MAK: Carcinogen category: 1; Germ cell mutagen group: 2; Skin absorption (H); Sensitization of skin (SH); (DFG 2012).
EU OEL ( selected): SCOEL recommendation available. 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. The substance may cause effects on the kidneys and liver. This may result in tissue lesions. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. Repeated or prolonged inhalation may cause nasal ulceration. This may result in perforation of the nasal septum. The substance may have effects on the kidneys. This may result in kidney impairment. This substance is carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 250°C
Melting point: 197°C
Density: 2.7 g/cm³
Solubility in water, g/100ml: 61.7 (good) 
The substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Do NOT take working clothes home.
Rinse contaminated clothing with plenty of water because of fire hazard.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact.
Depending on the degree of exposure, periodic medical examination is suggested. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
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       Toxicological Abbreviations