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TRIETHYLENETETRAMINE
ICSC: 1123
Peer-Review Status: 03.04.2009 Validated
N,N'-Bis(2-aminoethyl)-1,2-ethanediamine
3,6-Diazaoctane-1,8-diamine
Trientine
TETA 
CAS #: 112-24-3 RTECS #: YE6650000
UN #: 2259
EC #: 612-059-00-5
EINECS #: 203-950-6
    Formula: C6H18N4 / (NH2CH2CH2NHCH2)2
Molecular mass: 146.3

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. See Chemical dangers  NO open flames. NO contact with oxidants.  Use powder, alcohol-resistant foam, water spray, carbon dioxide. 
EXPLOSION Risk of fire and explosion on contact with oxidants. See Chemical Dangers.    In case of fire: keep cylinder cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Sore throat. Cough. Burning sensation. Laboured breathing. Shortness of breath.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer immediately for medical attention. 
Skin Redness. Pain. Skin burns. Blisters.  Protective gloves. Protective clothing.  First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer immediately for medical attention. 
Eyes Redness. Pain. Loss of vision. Severe deep burns.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal pain. Shock or collapse.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: C; R: 21-34-43-52/53; S: (1/2)-26-36/37/39-45-61 
UN Classification
UN Hazard Class: 8; UN Pack Group: II 
GHS Classification
Signal: Danger
Toxic in contact with skin
May be harmful if swallowed
Causes severe skin burns and eye damage
May cause allergy or asthma symptoms or breathing difficulties if inhaled
May cause an allergic skin reaction
Toxic to aquatic life
Toxic to aquatic life with long lasting effects 
corrskull;toxiccancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F1; R0.  Separated from food and feedstuffs. See Chemical Dangers. Cool. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-YELLOW HYGROSCOPIC VISCOUS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides. The substance is a strong base. It reacts violently with acid and is corrosive to aluminium, copper and zinc. Reacts violently with strong oxidants. This generates fire and explosion hazard. This produces toxic fumes. Attacks some coatings, some forms of plastic and rubber. 

Occupational exposure limits
TLV not established.
MAK: Sensitization of skin (SH); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Serious local effects by all routes of exposure. 

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 277°C
Melting point: -35°C
Density: 0.98 g/cm³
Solubility in water: miscible
Vapour pressure, Pa at 20°C: 1.3
Relative vapour density (air = 1): 5.04
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 135°C c.c.
Auto-ignition temperature: 335°C
Explosive limits, vol% in air: 1.1-?
Octanol/water partition coefficient as log Pow: -1.4/-1.66
Viscosity: 27.24 mm²/s at 20°C 
The substance is toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment. 

NOTES
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Triethylenetetramine  (SIDS)