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p-ANISIDINE
ICSC: 0971
Peer-Review Status: 01.04.2009 Validated
1-Amino-4-methoxybenzene
4-Methoxyaniline
4-Aminoanisole
4-Methoxybenzenamine 
CAS #: 104-94-9 RTECS #: BZ5450000
UN #: 2431
EC #: 612-112-00-2
EINECS #: 203-254-2
    Formula: C7H9NO / H2NC6H4OCH3
Molecular mass: 123.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Prevent deposition of dust. Closed system, dust explosion-proof electrical equipment and lighting.   
 
EXPOSURE   PREVENT DISPERSION OF DUST! STRICT HYGIENE!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Blue lips, fingernails and skin. Dizziness. Headache.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes Redness.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). 
Ingestion Nausea. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T+, N; R: 26/27/28-33-50; S: (1/2)-28-36/37-45-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Harmful if swallowed
May be harmful in contact with skin
Causes damage to blood
Causes damage to the blood through prolonged or repeated exposure
Toxic to aquatic life 
cancer;health hazexcl mark;warn

EMERGENCY RESPONSE SAFE STORAGE
  Separated from strong oxidants, strong bases, acids, chloroformates and food and feedstuffs. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-BROWN CRYSTALS WITH CHARACTERISTIC ODOUR. 

Physical dangers
As a result of flow, agitation, etc., electrostatic charges can be generated. Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
Decomposes on burning. This produces toxic fumes including nitrogen oxides. The solution in water is a weak base. Reacts with acids, chloroformates and strong oxidants. Attacks some coatings, some forms of plastic and rubber. 

Occupational exposure limits
TLV: 0.5mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2009).
MAK: Carcinogen category: 3B; Skin absorption (H); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The aerosol is irritating to the eyes and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Medical observation is indicated. See Notes. 

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in the formation of methaemoglobin and anaemia. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 243°C
Melting point: 57°C
Density (at °C): 1.07 g/cm³
Solubility in water, g/100ml at 20°C: 2.2 (moderate)
Vapour pressure, Pa at 20°C: 2
Relative vapour density (air = 1): 4.3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 122°C
Auto-ignition temperature: 515°C
Octanol/water partition coefficient as log Pow: 0.95  
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
See also ICSC 0970 o-Anisidine. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations