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o-ANISIDINE
ICSC: 0970
Peer-Review Status: 01.04.2009 Validated
1-Amino-2-methoxybenzene
2-Methoxyaniline
2-Aminoanisole
2-Methoxybenzenamine 
CAS #: 90-04-0 RTECS #: BZ5410000
UN #: 2431
EC #: 612-035-00-4
EINECS #: 201-963-1
    Formula: C7H9NO / NH2C6H4OCH3
Molecular mass: 123.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Blue lips, fingernails and skin. Dizziness. Headache.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer immediately for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes   Wear face shield.  Rinse with plenty of water (remove contact lenses if easily possible). 
Ingestion Nausea. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: T; R: 45-23/24/25-68; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Harmful if swallowed
May be harmful in contact with skin
May cause cancer
Causes damage to blood
May cause damage to blood through prolonged or repeated exposure
Harmful to aquatic life 
excl mark;warncancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
  Separated from strong oxidants, acids, chloroformates and food and feedstuffs. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
RED-TO-YELLOW OILY LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. 

Physical dangers
As a result of flow, agitation, etc., electrostatic charges can be generated. 

Chemical dangers
Decomposes on burning. This produces toxic fumes including nitrogen oxides. The solution in water is a weak base. Reacts with acids, chloroformates and strong oxidants. Attacks some coatings, some forms of plastic and rubber. 

Occupational exposure limits
TLV: 0.5mg/m³ as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued; (ACGIH 2009).
MAK: Carcinogen category: 2; Skin absorption (H); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Medical observation is indicated. See Notes. 

Effects of long-term or repeated exposure
This substance is possibly carcinogenic to humans. The substance may have effects on the blood. This may result in the formation of methaemoglobin and anaemia. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 224-225°C
Melting point: 5°C
Relative density (water = 1): 1.09
Solubility in water, g/100ml at 20°C: 1.5 (moderate)
Vapour pressure, kPa at 20°C: 5
Relative vapour density (air = 1): 4.3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 107°C c.c.
Auto-ignition temperature: 430°C
Octanol/water partition coefficient as log Pow: 1.18
Viscosity: 2.028 mm²/s at 55°C 
The substance is toxic to aquatic organisms. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
See also ICSC 0971 p-Anisidine. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations