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o-ANISIDINE
ICSC: 0970
Peer-Review Status: 11.04.2014 Validated
1-Amino-2-methoxybenzene
2-Methoxyaniline
2-Aminoanisole
2-Methoxybenzenamine
CAS #: 90-04-0 RTECS #: BZ5410000
UN #: 2431
EC #: 612-035-00-4
EINECS #: 201-963-1
    Formula: C7H9NO / NH2C6H4OCH3
Molecular mass: 123.2

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Blue lips, fingernails and skin. Headache. Dizziness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Administration of oxygen may be needed. Refer immediately for medical attention. See Notes. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Administration of oxygen may be needed. Remove contaminated clothes. Rinse and then wash skin with water and soap. See Notes. Refer immediately for medical attention. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). 
Ingestion Nausea. Further see Inhalation.  Do not eat, drink, or smoke during work.  Administration of oxygen may be needed. Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Collect leaking liquid in sealable containers. Absorb liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T; R: 45-23/24/25-68; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Harmful if swallowed
May be harmful in contact with skin
Suspected of causing cancer
Causes damage to blood
May cause damage to blood through prolonged or repeated exposure
Toxic to aquatic life 
excl mark;warncancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H2; F1; R0.  Store only in original container. Keep in a well-ventilated room. Separated from strong oxidants, acids, chloroformates and food and feedstuffs. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing. 

IMPORTANT DATA
Physical State; Appearance
RED-TO-YELLOW OILY LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
Decomposes on burning. This produces toxic fumes including nitrogen oxides, carbon monoxide and carbon dioxide. The solution in water is a weak base. Reacts with acids, chloroformates and strong oxidants. This generates fire and explosion hazard. Attacks some coatings, some forms of plastic and rubber. 

Occupational exposure limits
TLV: 0.5mg/m³ as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued; (ACGIH 2014).
MAK: Carcinogen category: 2; Skin absorption (H); (DFG 2013). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance may cause effects on the blood. This may result in the formation of methaemoglobin. See Notes. Exposure could cause haemolysis. This may result in haemolytic anaemia. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
The substance may have effects on the blood. This may result in the formation of methaemoglobin and anaemia. This substance is possibly carcinogenic to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 224-225°C
Melting point: 5°C
Density (at 20°C): 1.09 g/cm³
Solubility in water, g/100ml at 20°C: 1.5 (moderate)
Vapour pressure, kPa at 20°C: 5
Relative vapour density (air = 1): 4.3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 107°C c.c.
Auto-ignition temperature: 430°C
Octanol/water partition coefficient as log Pow: 1.18
Viscosity: 2.028 mm²/s at 55°C 
The substance is toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
See also ICSC 0971 p-Anisidine. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
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       Toxicological Abbreviations