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AZINPHOS-METHYL
ICSC: 0826
Peer-Review Status: 26.03.1998 Validated
Phosphorodithioic acid 0,0-dimethyl S-((4-oxo-11,2,3-benzotriazin-3-(4H)-yl)methyl) ester
S-3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-ylmethyl) O,O-dimethyl phosphorodithioate
CAS #: 86-50-0 RTECS #: TE1925000
UN #: 2783
EC #: 015-039-00-9
EINECS #: 201-676-1
    Formula: C10H12N3O3PS2
Molecular mass: 317.3

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Headache. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Dizziness. Wheezing. Laboured breathing. Convulsions. Unconsciousness.  Use ventilation (not if powder), local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Blurred vision.  Wear face shield or eye protection in combination with breathing protection if powder.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Vomiting. Diarrhoea. Blurred vision. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Do NOT wash away into sewer. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: complete protective clothing including self-contained breathing apparatus.  Do not transport with food and feedstuffs.
Severe marine pollutant. 
EC Classification
Symbol: T+, N; R: 24-26/28-43-50/53; S: (1/2)-28-36/37-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Fatal if swallowed, in contact with skin or if inhaled
Causes eye irritation
May cause an allergic skin reaction
Causes damage to central nervous system
Causes damage to the central nervous system through prolonged or repeated exposure
Very toxic to aquatic life with long lasting effects 
skull;toxiccancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61G41B.  Separated from food and feedstuffs. Well closed. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS CRYSTALS. 

Physical dangers
 

Chemical dangers
Decomposes above 200°C . Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides, phosphorus oxides and sulfur oxides. 

Occupational exposure limits
MAK (inhalable fraction): 0.2 mg/m³; Peak limitation category: II(8); Skin absorption (H); (DFG 2007). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of short-term exposure
The substance may cause effects on the nervous system. This may result in convulsions and respiratory failure. Cholinesterase inhibition. Exposure could cause unconsciousness and death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 73-74°C
Density: 1.4 g/cm³
Solubility in water: none
Vapour pressure, Pa at 20°C: <0.001
Octanol/water partition coefficient as log Pow: 2.75  
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to bees. Avoid release to the environment in circumstances different to normal use. 

NOTES
The technical material is a brown waxy solid.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of acute poisoning do not become manifest until 0.5 to several hours.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Do NOT take working clothes home.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
If the substance is formulated with solvents also consult the ICSCs of these materials.
Guthion and Gusathion M are trade names.
Card has been partially updated in March 2008: see Occupational Exposure Limits; Packaging and Labelling.
Card has been partially updated in October 2013: see GHS classification. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Azinphos-Methyl (FAO Meeting Report PL/1965/10/1)
       Azinphos-methyl (FAO/PL:1968/M/9/1)
       Azinphos-methyl (WHO Pesticide Residues Series 2)
       Azinphos-methyl (WHO Pesticide Residues Series 3)
       Azinphos-methyl (WHO Pesticide Residues Series 4)
       Azinphos-methyl (Pesticide residues in food: 1991 evaluations Part II Toxicology)