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| TYPES OF HAZARD / EXPOSURE | ACUTE HAZARDS / SYMPTOMS | PREVENTION | FIRST AID / FIRE FIGHTING |
| FIRE |
Combustible.
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NO open flames. NO contact with strong oxidants.
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water spray, foam, powder, carbon dioxide
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| EXPLOSION |
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| EXPOSURE |
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AVOID ALL CONTACT! PREVENT DISPERSION OF DUST!
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IN ALL CASES CONSULT A DOCTOR!
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| Inhalation |
Coughing up blood. Blood in the urine. Bleeding under the skin. Confusion. Symptoms may be delayed (see Notes).
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Closed system.
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Refer immediately for medical attention.
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| Skin |
Easily absorbed. (See Inhalation).
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Protective gloves. Protective clothing.
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Remove contaminated clothes. (See Notes) Rinse and then wash skin with water and soap. Refer immediately for medical attention.
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| Eyes |
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Face shield. or eye protection in combination with breathing protection if powder.
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Rinse with plenty of water (remove contact lenses if easily possible).
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| Ingestion |
Diarrhoea. Nausea. Vomiting. Abdominal pain. (Further see Inhalation).
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Do not eat, drink, or smoke during work. Wash hands before eating.
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Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention.
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| SPILLAGE DISPOSAL | PACKAGING & LABELLING | |||||||
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Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place.
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Unbreakable packaging; put breakable packaging into closed unbreakable container. Do not transport with food and feedstuffs. Note: E EU Classification Symbol: T R: 61-48/25-52/53 S: 53-45-61 UN Classification UN Hazard Class: 6.1 UN Pack Group: I GHS Classification Danger Fatal if swallowed or if inhaled Harmful in contact with skin May damage fertility or the unborn child Causes damage to blood system Causes damage to blood system through prolonged or repeated exposure Harmful to aquatic life | |||||||
| EMERGENCY RESPONSE | STORAGE | |||||||
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Separated from strong oxidants, food and feedstuffs. Well closed. Store in an area without drain or sewer access.
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| IMPORTANT DATA | |||
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PHYSICAL STATE; APPEARANCE: COLOURLESS TO WHITE CRYSTALLINE POWDER CHEMICAL DANGERS: Reacts violently with strong oxidants causing fire and explosion hazard. The substance decomposes on heating , producing irritating fumes. OCCUPATIONAL EXPOSURE LIMITS: TLV: as TWA 0.1 mg/m³ as aerosol and vapor (ACGIH 2010). MAK: 0.02 mg/m³ Peak limitation category: II(8) skin absorption (H); Pregnancy risk group: B (DFG 2010). |
ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. INHALATION RISK: A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the blood , resulting in bleeding. The effects may be delayed. Medical observation is indicated. See Notes. Exposure may result in death. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the blood , resulting in bleeding. Causes toxicity to human reproduction or development. | ||
| PHYSICAL PROPERTIES | |||
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Decomposes Melting point: 161°C Relative density (water = 1): 1.4 Solubility in water, g/100 ml at 20°C: 0.0017 (very poor) Vapour pressure, Pa at 20°C: negligible Relative vapour density (air = 1): 10.6 |
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00 Octanol/water partition coefficient as log Pow: 2.6 | ||
| ENVIRONMENTAL DATA | |||
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The substance is harmful to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to mammals. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.
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| NOTES | |||
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Warfarin is usually available as the water soluble sodium salt (CAS 129-06-6). The physical properties above refer to the parent substance. The symptoms of bleeding may become manifest after one or two days. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Do NOT take working clothes home. This CAS number is for the racemic mixture; other CAS numbers: 5543-57-7 (S-warfarin), 5543-58-8 (R-warfarin)
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| ADDITIONAL INFORMATION | |||
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| © IPCS, CEC 2005 | |||
