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MALEIC ANHYDRIDE
ICSC: 0799
Peer-Review Status: 10.09.1997 Validated
2,5-Furandione
Dihydro-2,5-dioxofuran
Maleic acid anhydride
cis-Butenedioic anhydride 
CAS #: 108-31-6 RTECS #: ON3675000
UN #: 2215
EC #: 607-096-00-9
EINECS #: 203-571-6
    Formula: C4H2O3
Molecular mass: 98.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames.  Use water spray, alcohol-resistant foam, carbon dioxide. NO powder. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent deposition of dust.   
 
EXPOSURE   STRICT HYGIENE! PREVENT DISPERSION OF DUST!   
Inhalation Burning sensation. Cough. Sore throat. Shortness of breath. Wheezing.  Use local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer for medical attention. 
Skin Dry skin. Redness. Pain. See Notes.  See Notes. Protective clothing.  First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. 
Eyes Redness. Pain. Burns.  Wear safety goggles or eye protection in combination with breathing protection if powder.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Nausea. Abdominal pain. Burning sensation. Vomiting. Diarrhoea.  Do not eat, drink, or smoke during work.  Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: face shield, thermal gloves, chemical protection suit and particulate filter respirator adapted to the airborne concentration of the substance. See Notes. Sweep spilled substance into covered containers.  Airtight.
Do not transport with food and feedstuffs. 
EC Classification
Symbol: C; R: 22-34-42/43; S: (2)-22-26-36/37/39-45 
UN Classification
UN Hazard Class: 8; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-80S2215-S.
NFPA Code: H3; F1; R1. 
Dry. Separated from strong oxidants, strong bases and food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS OR WHITE CRYSTALS WITH PUNGENT ODOUR. 

Physical dangers
 

Chemical dangers
The solution in water is a medium strong acid. Reacts with strong bases and strong oxidants. 

Occupational exposure limits
TLV: 0.1ppm as TWA; (SEN); A4 (not classifiable as a human carcinogen); (ACGIH 2005).
MAK: 0.1 ppm, 0.41 mg/m³; Peak limitation category: I(1); Pregnancy risk group: C; Sensitization of respiratory tract and skin (SAH); (DFG 2005). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is severely irritating to the eyes, skin and respiratory tract. Inhalation may cause asthma-like reactions. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 202°C
Melting point: 53°C
Density: 1.5 g/cm³
Solubility in water: reaction
Vapour pressure, Pa at 25°C: 25
Relative vapour density (air = 1): 3.4
Flash point: 102°C c.c.
Auto-ignition temperature: 477°C
Explosive limits, vol% in air: 1.4-7.1 
 

NOTES
Reacts violently with fire extinguishing agents such as powder.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.
Maleic anhydride is transported also as hot liquid (70°C); contact of the skin should be avoided.
The odour warning when the exposure limit value is exceeded is insufficient. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations