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DEMETON-S-METHYL
ICSC: 0705
Peer-Review Status: 04.08.1997 Validated
S-2-Ethylthioethyl O,O-dimethyl phosphorothioate
Phosphorothioic acid, S-(2-(ethylthio)ethyl)O,O-dimethyl ester 
CAS #: 919-86-8 RTECS #: TG1750000
UN #: 3018
EC #: 015-031-00-5
EINECS #: 213-052-6
    Formula: C6H15O3PS2 / (CH3O)2P(O)SCH2CH2SCH2CH3
Molecular mass: 230.3

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION Risk of fire and explosion if formulations contain flammable/explosive solvents.     
 
EXPOSURE   PREVENT GENERATION OF MISTS! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Vomiting. Abdominal cramps. Diarrhoea. Unconciousness. Dizziness. Laboured breathing. Weakness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Pupillary constriction. Blurred vision.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Convulsions. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T, N; R: 24/25-51/53; S: (1/2)-28-36/37-45-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT6-II.  Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-PALE YELLOW OILY LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including phosphorus oxides and sulfur oxides. 

Occupational exposure limits
TLV: 0.05mg/m³ as TWA; (skin); (SEN); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The substance may cause effects on the nervous system. This may result in convulsions, respiratory failure and death. Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point at 0.13kPa: 118°C
Relative density (water = 1): 1.2
Solubility in water, g/100ml at 20°C: 0.33
Vapour pressure, Pa at 20°C: 0.048
Relative vapour density (air = 1): 7.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Octanol/water partition coefficient as log Pow: 1.32  
The substance is toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to bees, mammals and birds. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvents also consult the ICSCs of these materials.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home.
Azotox, Demetox, Duratox, Metasystox i, Metasystox 55, Mifatox, Persyst are trade names.
Also consult ICSC 0429 (Demeton-O-methyl).
Card has been partly updated in October 2004 and 2005.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Demeton-s-methyl (EHC 197, 1997)
       Demeton-s-methyl (PDS)
       Demeton-s-methyl (Pesticide residues in food: 1979 evaluations)
       Demeton-S-methyl (Pesticide residues in food: 1984 evaluations)