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TETRAHYDROFURANICSC: 0578
July 1997
CAS #: 109-99-9Tetramethylene oxide
Diethylene oxide
1,4-Epoxybutane
Oxacyclopentane
UN #: 2056
EINECS #: 203-726-8

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Highly flammable.  Vapour/air mixtures are explosive.  NO open flames, NO sparks and NO smoking.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.  Use water in large amounts, powder, alcohol-resistant foam, carbon dioxide.  In case of fire: keep drums, etc., cool by spraying with water. 

 PREVENT GENERATION OF MISTS!  
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Cough. Dizziness. Headache. Nausea. Sore throat. Unconsciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin Dry skin. Redness. Pain.  Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

 

Transportation
UN Classification
UN Hazard Class: 3; UN Pack Group: II 

STORAGE
Fireproof. See Chemical Dangers. Store only if stabilized. 
PACKAGING
Airtight. 
TETRAHYDROFURAN ICSC: 0578
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
The substance can form explosive peroxides. Reacts violently with strong oxidants, strong bases and some metal halides. This generates fire and explosion hazard. Attacks some forms of plastic, rubber and coatings. 

Formula: C4H8O / (CH2)3CH2O
Molecular mass: 72.1
Boiling point: 66°C
Melting point: -108.5°C
Relative density (water = 1): 0.89
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 19.3
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.28
Flash point: -14.5°C c.c.
Auto-ignition temperature: 321°C
Explosive limits, vol% in air: 2-11.8 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion. 

Effects of short-term exposure
The substance and the vapour are irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system at high levels. This may result in narcosis. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. 


Occupational exposure limits
TLV: 50 ppm as TWA; 100 ppm as STEL; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: 150 mg/m3, 50 ppm; peak limitation category: I(2); skin absorption (H); carcinogen category: 4; pregnancy risk group: C.
EU-OEL: 150 mg/m3, 50 ppm as TWA; 300 mg/m3, 100 ppm as STEL; (skin) 

ENVIRONMENT
 

NOTES
P-Cresol or hydroquinone are commonly used stabilizers.
Use of alcoholic beverages enhances the harmful effect.
An added stabilizer or inhibitor can influence the toxicological properties of this substance, consult an expert.
The odour warning when the exposure limit value is exceeded is insufficient.
Check for peroxides prior to distillation; eliminate if found. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: F, Xi; R: 11-19-36/37; S: (2)-16-29-33 

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    See Also:
       Toxicological Abbreviations