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TETRAHYDROFURAN
ICSC: 0578
Peer-Review Status: 10.07.1997 Validated
Tetramethylene oxide
Diethylene oxide
1,4-Epoxybutane
Oxacyclopentane 
CAS #: 109-99-9 RTECS #: LU5950000
UN #: 2056
EC #: 603-025-00-0
EINECS #: 203-726-8
    Formula: C4H8O / (CH2)3CH2O
Molecular mass: 72.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Highly flammable.  NO open flames, NO sparks and NO smoking.  Use water in large amounts, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS!   
Inhalation Cough. Dizziness. Headache. Nausea. Sore throat. Unconciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin Dry skin. Redness. Pain.  Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Airtight. 
EC Classification
Symbol: F, Xi; R: 11-19-36/37; S: (2)-16-29-33 
UN Classification
UN Hazard Class: 3; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30S2056 or 30GF1-I+II.
NFPA Code: H2; F3; R1. 
Fireproof. See Chemical Dangers. Store only if stabilized. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
The substance can form explosive peroxides. Reacts violently with strong oxidants, strong bases and some metal halides. This generates fire and explosion hazard. Attacks some forms of plastic, rubber and coatings. 

Occupational exposure limits
TLV: 50 ppm as TWA; 100 ppm as STEL; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2005).
MAK: 50 ppm, 150 mg/m³; Carcinogen category: 4; Peak limitation category: I(2); Pregnancy risk group: C; Skin absorption (H); (DFG 2005). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance and the vapour are irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system at high levels. This may result in narcosis. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 66°C
Melting point: -108.5°C
Relative density (water = 1): 0.89
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 19.3
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.28
Flash point: -14.5°C c.c.
Auto-ignition temperature: 321°C
Explosive limits, vol% in air: 2-11.8 
 

NOTES
p-Cresol or hydroquinone are commonly used stabilizers.
Use of alcoholic beverages enhances the harmful effect.
An added stabilizer or inhibitor can influence the toxicological properties of this substance, consult an expert.
The odour warning when the exposure limit value is exceeded is insufficient.
Check for peroxides prior to distillation; eliminate if found.
Card has been partly updated in October 2005.
See sections Occupational Exposure Limits, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations