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DIETHYL SULFATE
ICSC: 0570
Peer-Review Status: 12.04.2013 Validated
Sulfuric acid diethyl ester
DES 
CAS #: 64-67-5 RTECS #: WS7875000
UN #: 1594
EC #: 016-027-00-6
EINECS #: 200-589-6
    Formula: C4H10O4S / (C2H5)2SO4
Molecular mass: 154.2

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames. See Chemical Dangers.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Sore throat. Laboured breathing. Shortness of breath. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer immediately for medical attention. 
Skin Redness. Pain. Serious skin burns.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer immediately for medical attention. 
Eyes Redness. Pain. Severe burns.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Burns in mouth and throat. Burning sensation behind the breastbone. Abdominal pain. Shock or collapse.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T; R: 45-46-20/21/22-34; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Toxic in contact with skin or if inhaled
Harmful if swallowed
Causes severe skin burns and eye damage
May cause genetic defects
May cause cancer 
corrskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F1; R1.  Separated from food and feedstuffs. Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
OILY COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces flammable and toxic fumes. Reacts violently with ammonia, strong oxidants, strong bases and powdered metals. This generates fire hazard. Reacts with water and moisture. This produces sulfuric acid and ethanol. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):.
MAK: Carcinogen category: 2; Germ cell mutagen group: 2; Skin absorption (H); (DFG 2012). 

Routes of exposure
The substance can be absorbed into the body by inhalation, by ingestion and through the skin. 

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Inhalation may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 209°C
Melting point: -25°C
Relative density (water = 1): 1.2
Solubility in water: reaction
Vapour pressure, Pa at 20°C: 20
Relative vapour density (air = 1): 5.3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.001
Flash point: 104°C c.c.
Auto-ignition temperature: 360°C
Explosive limits, vol% in air: 1.8-12.2
Octanol/water partition coefficient as log Pow: 1.14  
The substance is harmful to aquatic organisms. 

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Diethyl Sulfate  (IARC Summary & Evaluation, Volume 54, 1992)
       Diethyl Sulfate  (IARC Summary & Evaluation, Volume 71, 1999)