IPCS INCHEM Home
DIETHYL SULFATE
ICSC: 0570
Peer-Review Status: 23.03.1999 Validated
Sulfuric acid diethyl ester
DES 
CAS #: 64-67-5 RTECS #: WS7875000
UN #: 1594
EC #: 016-027-00-6
EINECS #: 200-589-6
    Formula: C4H10O4S / (C2H5)2SO4
Molecular mass: 154.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Laboured breathing. Shortness of breath. Sore throat. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer for medical attention. 
Skin Redness. Serious skin burns. Pain.  Protective gloves. Protective clothing.  First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention . 
Eyes Redness. Pain. Blurred vision. Severe deep burns.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Burning sensation. Nausea. Sore throat.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T; R: 45-46-20/21/22-34; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61G16B.
NFPA Code: H3; F1; R1. 
Separated from food and feedstuffs. Dry. Well closed. Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
OILY COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces flammable and toxic fumes. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):.
MAK: Carcinogen category: 2; Germ cell mutagen group: 2; Skin absorption (H); (DFG 2009). 

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. Inhalation of of the aerosol may cause lung oedema. See Notes. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 209°C
Melting point: -25°C
Relative density (water = 1): 1.2
Solubility in water, g/100ml at 25°C: 0.7 (poor)
Vapour pressure, Pa at 20°C: 20
Relative vapour density (air = 1): 5.3
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.001
Flash point: 104°C c.c.
Auto-ignition temperature: 436°C
Explosive limits, vol% in air: 4.1-?
Octanol/water partition coefficient as log Pow: 1.14  
The substance is harmful to aquatic organisms. 

NOTES
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation is therefore essential.
Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
Rinse contaminated clothes (fire hazard) with plenty of water.
Card has been partially updated in August 2007: see Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Diethyl Sulfate  (IARC Summary & Evaluation, Volume 54, 1992)
       Diethyl Sulfate  (IARC Summary & Evaluation, Volume 71, 1999)