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NICOTINE
ICSC: 0519
Peer-Review Status: 04.09.1997 Validated
(S)-3-(1-Methylpyrrolidin-2-yl)pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
beta-Pyridyl-alpha-N-methylpyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine 
CAS #: 54-11-5 RTECS #: QS5250000
UN #: 1654
EC #: 614-001-00-4
EINECS #: 200-193-3
    Formula: C10H14N2
Molecular mass: 162.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Above 95°C explosive vapour/air mixtures may be formed.  Above 95°C use a closed system and ventilation.   
 
EXPOSURE   PREVENT GENERATION OF MISTS! AVOID EXPOSURE OF (PREGNANT) WOMEN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Burning sensation. Nausea. Vomiting. Convulsions. Abdominal pain. Diarrhoea. Headache. Sweating. Weakness. Dizziness. Confusion.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Burning sensation. See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Pain. Redness.  Wear safety goggles, face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T+, N; R: 25-27-51/53; S: (1/2)-36/37-45-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61G68.
NFPA Code: H4; F1; R0. 
Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Dry. Ventilation along the floor. 

IMPORTANT DATA
Physical State; Appearance
OILY COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides and carbon monoxide. Reacts violently with strong oxidants. 

Occupational exposure limits
TLV: 0.5mg/m³ as TWA; (skin); (ACGIH 1996). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes and skin. The substance may cause effects on the cardiovascular system and central nervous system. This may result in convulsions and respiratory failure. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 247°C
Melting point: -80°C
Relative density (water = 1): 1.01
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 0.006
Relative vapour density (air = 1): 5.6
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 95°C c.c.
Auto-ignition temperature: 240°C
Explosive limits, vol% in air: 0.7-4
Octanol/water partition coefficient as log Pow: 1.2  
The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use. 

NOTES
Destruxol, XL All Insecticide are trade names.
Card has been partially updated in August 2007: see Ingestion First Aid, Occupational Exposure Limits EU Classification. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Nicotine (PIM 373)