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METHYL ISOBUTYL KETONE
ICSC: 0511
Peer-Review Status: 10.07.1997 Validated
4-Methyl-2-pentanone
Isopropylacetone
Hexone 
CAS #: 108-10-1 RTECS #: SA9275000
UN #: 1245
EC #: 606-004-00-4
EINECS #: 203-550-1
    Formula: C6H12O / CH3COCH2CH(CH3)2
Molecular mass: 100.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Highly flammable.  NO open flames, NO sparks and NO smoking.  Use powder, AFFF, foam, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS!   
Inhalation Cough. Diarrhoea. Dizziness. Headache. Nausea. Sore throat. Unconciousness. Vomiting. Weakness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin Dry skin. Redness. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Airtight. 
EC Classification
Symbol: F, Xn; R: 11-20-36/37-66; S: (2)-9-16-29; Note: 6 
UN Classification
UN Hazard Class: 3; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30S1245.
NFPA Code: H2; F3; R0. 
Fireproof. Separated from strong oxidants. Well closed. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour mixes well with air, explosive mixtures are easily formed. 

Chemical dangers
The substance can form explosive peroxides on exposure to air. Reacts violently with strong oxidants and strong reducing agents. 

Occupational exposure limits
TLV: 50 ppm as TWA; 75 ppm as STEL; BEI issued; (ACGIH 2004).
MAK: 20 ppm, 83 mg/m³; Peak limitation category: I(2); Pregnancy risk group: C; Skin absorption (H); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance and the vapour are irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system at high concentrations. This may result in narcosis. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 117-118°C
Melting point: -84.7°C
Relative density (water = 1): 0.80
Solubility in water, g/100ml at 20°C: 1.91
Vapour pressure, kPa at 20°C: 2.1
Relative vapour density (air = 1): 3.45
Flash point: 14°C c.c.
Auto-ignition temperature: 460°C
Explosive limits, vol% in air: 1.4-7.5
Octanol/water partition coefficient as log Pow: 1.38  
 

NOTES
MIBK is commonly used name.
Check for peroxides prior to distillation; eliminate if found.
Card has been partly updated in October 2004.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Methyl isobutyl ketone (EHC 117, 1990)
       Methyl isobutyl ketone (HSG 58, 1991)