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N,N-DIMETHYLFORMAMIDE
ICSC: 0457
Peer-Review Status: 11.04.2014 Validated
Dimethylformamide
DMF
DMFA
N-Formyldimethylamine
CAS #: 68-12-2 RTECS #: LQ2100000
UN #: 2265
EC #: 616-001-00-X
EINECS #: 200-679-5
    Formula: C3H7NO / HCON(CH3)2
Molecular mass: 73.1

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames, NO sparks and NO smoking. NO contact with oxidizing agents.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Above 58°C explosive vapour/air mixtures may be formed.  Above 58°C use a closed system and ventilation.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!   
Inhalation Sore throat. Abdominal pain. Diarrhoea. Vomiting. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! See Inhalation.  Barrier cream. Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Aspiration hazard! Abdominal pain. Jaundice.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
Symbol: T; R: 61-20/21-36; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 3; UN Pack Group: III 
GHS Classification
Signal: Danger
Flammable liquid and vapour
May be harmful if swallowed or in contact with skin
Harmful if inhaled
Causes serious eye irritation
May damage fertility or the unborn child
May cause damage to liver
May be harmful if swallowed and enters airways 
flam;flameexcl mark;warncancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H2; F2; R0.  Separated from incompatible materials. See Chemical Dangers. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides. Reacts violently with strong oxidants, halogens, halogenated hydrocarbons and nitrates. Attacks some plastics and rubber. 

Occupational exposure limits
TLV: 10ppm as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2014).
MAK: 5 ppm, 15 mg/m³; Peak limitation category: II(2); Pregnancy risk group: B; Skin absorption (H); BAT issued; (DFG 2014).
EU OEL: 5 ppm, 15 mg/m³ as TWA; 10 ppm, 30 mg/m³ as STEL. 

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the liver. This may result in tissue lesions. The effects may be delayed. Medical observation is indicated. See Notes. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis. 

Effects of long-term or repeated exposure
The substance may have effects on the liver. This may result in impaired functions. Tumours have been detected in experimental animals but may not be relevant to humans. Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 153°C
Melting point: -61°C
Relative density (water = 1): 0.95
Solubility in water: miscible
Vapour pressure, kPa at 25°C: 0.49
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 58°C c.c.
Auto-ignition temperature: 440°C
Octanol/water partition coefficient as log Pow: -0.87
Viscosity: 0.85 mm²/s at 25°C 
 

NOTES
The symptoms of poisoning do not become manifest until a few hours or even days have passed.
Use of alcoholic beverages enhances the harmful effect.
Environmental effects from the substance have been investigated but none has been found. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
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    See Also:
       Toxicological Abbreviations