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N,N-DIMETHYLFORMAMIDE
ICSC: 0457
Peer-Review Status: 10.04.2000 Validated
Dimethylformamide
DMF
DMFA
N-Formyldimethylamine 
CAS #: 68-12-2 RTECS #: LQ2100000
UN #: 2265
EC #: 616-001-00-X
EINECS #: 200-679-5
    Formula: C3H7NO / HCON(CH3)2
Molecular mass: 73.09

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames, NO sparks and NO smoking. NO contact with oxidizing agents.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Above 58°C explosive vapour/air mixtures may be formed.  Above 58°C use a closed system and ventilation.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS! AVOID EXPOSURE OF (PREGNANT) WOMEN!   
Inhalation Abdominal pain. Diarrhoea. Nausea. Vomiting. Flushing of the face.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED!  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.  Rinse mouth. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
Symbol: T; R: 61-20/21-36; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 3; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-30S2265 or 30GF1-III.
NFPA Code: H1; F2; R0. 
Separated from strong oxidants and halogens. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-YELLOW LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including nitrogen oxides. Reacts violently with oxidants, nitrates and halogenated hydrocarbons. Attacks some plastics and rubber. 

Occupational exposure limits
TLV: 10ppm as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2004).
MAK: 5 ppm, 15 mg/m³; Peak limitation category: II(4); Pregnancy risk group: B; Skin absorption (H); (DFG 2005). 

Routes of exposure
The substance can be absorbed into the body by inhalation and through the skin. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes. The substance may cause effects on the liver. This may result in jaundice. See Notes. 

Effects of long-term or repeated exposure
The substance may have effects on the liver. This may result in impaired functions. Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 153°C
Melting point: -61°C
Relative density (water = 1): 0.95
Solubility in water: miscible
Vapour pressure, Pa at 25°C: about 492
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 58°C c.c.
Auto-ignition temperature: 445°C
Explosive limits, vol% in air: 2.2-15.2 (at 100°C)
Octanol/water partition coefficient as log Pow: -0.87  
 

NOTES
Use of alcoholic beverages enhances the harmful effect.
Resulting symptoms could be delayed from several hours up to several days.
Environmental effects from the substance have been investigated but none have been found.
Card has been partly updated in October 2005.
See sections Occupational Exposure Limits, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations