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COUMAPHOS
ICSC: 0422
Peer-Review Status: 12.04.2013 Validated
O-3-Chloro-4-methyl-2-oxo-2H-chromen-7-yl O,O-diethyl phosphorothioate
Phosphorothioic acid O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester
O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate
O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate 
CAS #: 56-72-4 RTECS #: GN6300000
UN #: 3027
EC #: 015-038-00-3
EINECS #: 200-285-3
    Formula: C14H16ClO5PS
Molecular mass: 362.78

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Not combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.    In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION     In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  FIRST AID: USE PERSONAL PROTECTION. 
Inhalation Headache. Sweating. Weakness. Nausea. Vomiting. Pupillary constriction, muscle cramp, excessive salivation. Laboured breathing. Unconciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . See Notes. 
Eyes Redness.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Diarrhoea. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. NO mouth-to-mouth artificial respiration. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance and protective clothing. Do NOT wash away into sewer. Collect the spilled substance into containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: T+, N; R: 21-28-50/53; S: (1/2)-28-36/37-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Fatal if swallowed or if inhaled
Harmful in contact with skin
Very toxic to aquatic life with long lasting effects 
skull;toxicexcl mark;warnenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
  Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS CRYSTALS WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including sulfur oxides, phosphorus oxides and hydrogen chloride. 

Occupational exposure limits
TLV (inhalable vapor and aerosol): 0.05mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2012).
MAK (not established): (DFG 2012). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
Cholinesterase inhibition. The substance may cause effects on nervous system. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 91°C
Density: 1.47 g/cm³
Solubility in water: none
Vapour pressure at 20°C: negligible
Octanol/water partition coefficient as log Pow: 4.13  
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to fish, crustacea, birds and mammals. Bioaccumulation of this chemical may occur in fish. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Isolate contaminated clothing by sealing in a bag or other container. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Coumaphos (FAO/PL:1968/M/9/1)
       Coumaphos (WHO Pesticide Residues Series 2)
       Coumaphos (WHO Pesticide Residues Series 5)
       Coumaphos (Pesticide residues in food: 1978 evaluations)
       Coumaphos (Pesticide residues in food: 1980 evaluations)
       Coumaphos (Pesticide residues in food: 1983 evaluations)
       Coumaphos (Pesticide residues in food: 1990 evaluations Toxicology)