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CAFFEINE
ICSC: 0405
Peer-Review Status: 27.03.1998 Validated
1,3,7-Trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Methyltheobromine
Methyltheophylline 
CAS #: 58-08-2 RTECS #: EV6475000
UN #: 1544
EC #: 613-086-00-5
EINECS #: 200-362-1
    Formula: C8H10N4O2
Molecular mass: 194.19

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST!   
Inhalation See Ingestion.  Use local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes   Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Headache. Dizziness. Abdominal cramps. Nausea. Vomiting. Convulsions. Tremor.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: Xn; R: 22; S: (2) 
UN Classification
UN Hazard Class: 6.1 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT2-III.  Separated from food and feedstuffs. Well closed. 

IMPORTANT DATA
Physical State; Appearance
ODOURLESS WHITE CRYSTALS OR CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on burning. This produces toxic fumes including nitrogen oxides. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
The substance can be absorbed into the body by inhalation and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. 

Effects of short-term exposure
The substance may cause effects on the central nervous system and cardiovascular system. This may result in insomnia, excitement, tachycardia and polyuria. 

Effects of long-term or repeated exposure
Animal tests show that this substance possibly causes toxic effects upon human reproduction. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Sublimation point: 178°C
Melting point: 238°C
Density: 1.23 g/cm³
Solubility in water, g/100ml: 2.17
Octanol/water partition coefficient as log Pow: -0.07  
 

NOTES
Card has been partly updated in October 2005.
See section Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Caffeine (IARC Summary & Evaluation, Volume 51, 1991)