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ARSENIC TRIOXIDE
ICSC: 0378
Peer-Review Status: 13.11.2008 Validated
Arsenic(III)oxide
Arsenous oxide anhydride
White arsenic
Arsenous acid anhydride
Diarsenic trioxide 
CAS #: 1327-53-3 RTECS #: CG3325000
UN #: 1561
EC #: 033-003-00-0
EINECS #: 215-481-4
    Formula: As2O3
Molecular mass: 197.8

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.    In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Burning sensation behind the breastbone. Cough. Dizziness. Headache. Shortness of breath. Sore throat. Weakness. See Ingestion. Symptoms may be delayed. See Notes.  Use closed system and ventilation.  Fresh air, rest. Half-upright position. Refer for medical attention. 
Skin Redness. Pain. Blisters. Skin burns.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain. Burns.  Wear face shield or eye protection in combination with breathing protection if powder.  Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Burns in mouth and throat. Abdominal cramps. Diarrhoea. Nausea. Vomiting. Shock or collapse.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention . See Notes. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable, plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Unbreakable packaging.
Put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: T+, N; R: 45-28-34-50/53; S: 53-45-60-61; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Toxic if swallowed
Causes severe skin burns and eye damage
Suspected of causing genetic defects
May cause cancer
May damage fertility or the unborn child
Causes damage to blood, central nervous and cardiovascular system and liver
May cause respiratory irritation
Causes damage to the bone marrow, the central nervous system, the kidneys and the liver through prolonged or repeated exposure
Very toxic to aquatic life 
corrskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT5-II.
NFPA Code: H3; F0; R2. 
Provision to contain effluent from fire extinguishing. Separated from combustible substances, reducing agents and food and feedstuffs. Well closed. Store only in original container. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
WHITE LUMPS OR CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
The solution is a weak acid. It reacts with reducing agents. This produces very toxic gas (arsine - see ICSC 0222). Decomposes on contact with hot surfaces or flames. This produces toxic fumes of arsenic oxides. It reacts with metals. This generates fire and explosion hazard. 

Occupational exposure limits
TLV (as As): 0.01mg/m³ as TWA; A1 (confirmed human carcinogen); (ACGIH 2008).
MAK: Carcinogen category: 1; Germ cell mutagen group: 3A; (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. The substance may cause effects on the blood, cardiovascular system, nervous system and liver. Inhalation may cause lung oedema. See Notes. Exposure could cause death. The effects may be delayed. See Notes. Medical observation is indicated. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the bone marrow (hematopoietic changes), cardiovascular system, central nervous system, peripheral nervous system, kidneys and liver. This may result in anaemia and impaired functions. This substance is carcinogenic to humans. Causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 460°C
Sublimation point: 193°C
Melting point: 275-313°C
Relative density (water = 1): 3.7-4.2
Solubility in water, g/100ml at 20°C: 1.2-3.7  
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds, fish and mammals. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Do NOT take working clothes home.
Physical properties depend on crystalline form of the substance.
The symptoms of acute poisoning appear ½ to 1 hour after the exposure but may be delayed many hours.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Refer for medical attention if breathing difficulties and/or fever develop.
Depending on the degree of exposure, periodic medical examination is suggested.
The recommendations on this Card also apply to inorganic trivalent arsenic compounds (arsenites).. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Arsenic trioxide (UKPID)