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2,4-TOLUENE DIISOCYANATE
ICSC: 0339
Peer-Review Status: 13.03.1995 Validated
4-Methyl-meta-phenylene diisocyanate
2,4-Diisocyanatotoluene
2,4-Diisocyanato-1-methylbenzene 
CAS #: 584-84-9 RTECS #: CZ6300000
UN #: 2078
EC #: 615-006-00-4
EINECS #: 209-544-5
    Formula: C9H6N2O2 / CH3C6H3(NCO)2
Molecular mass: 174.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames. NO contact with water.  Use powder, carbon dioxide. 
EXPLOSION Risk of fire and explosion as a result of decomposition when heated.    In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. Combat fire from a sheltered position. 
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Abdominal pain. Cough. Nausea. Shortness of breath. Sore throat. Vomiting. Symptoms may be delayed. See Notes.  Use local exhaust. Use breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Burning sensation. Pain.  Protective gloves. Protective clothing.  Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain. Blurred vision.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in covered containers as far as possible. Treat remaining liquid with a mixture of ammonia (4-8%), detergent (2%), and water. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. If solid: sweep spilled substance into containers.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T+; R: 26-36/37/38-40-42/43-52/53; S: (1/2)-23-36/37-45-61; Note: C 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S2078 or 61GT1-II.
NFPA Code: H3; F1; R1. 
Store between 20°C and 25°C. Separated from food and feedstuffs. See Chemical Dangers. Dry. Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-PALE YELLOW LIQUID OR CRYSTALS WITH PUNGENT ODOUR. TURNS PALE YELLOW ON EXPOSURE TO AIR. 

Physical dangers
 

Chemical dangers
The substance may polymerize under the influence of bases, tertiary amines and acyl chlorides. This generates fire or explosion hazard. On combustion, forms toxic gases and vapours including nitrogen oxides and isocyanates. Reacts readily with water, acids and alcohols. This generates pressure-rise explosion hazard. 

Occupational exposure limits
TLV: 0.005 ppm as TWA; 0.02 ppm as STEL; (SEN); A4 (not classifiable as a human carcinogen); (ACGIH 2004).
MAK: Carcinogen category: 3A; Sensitization of respiratory tract (SA); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance, the vapour of this substance and the aerosol are irritating to the eyes, skin and respiratory tract. Inhalation of the vapour may cause asthma-like reactions. Inhalation of the vapour may cause chemical bronchitis, pneumonitis and lung oedema. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. This substance is possibly carcinogenic to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 251°C
Melting point: 22°C
Relative density (water = 1): 1.2
Solubility in water: reaction
Vapour pressure, Pa at 20°C: 1.3
Relative vapour density (air = 1): 6.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 127°C c.c.
Auto-ignition temperature: 620°C
Explosive limits, vol% in air: 0.9-9.5
Octanol/water partition coefficient as log Pow: 0.21  
 

NOTES
Technical toluene diisocyanate is a mixture of 2,4- and 2,6-isomers (80:20), TDI is a common name.
Depending on the degree of exposure, periodic medical examination is suggested.
Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.
The odour warning when the exposure limit value is exceeded is insufficient.
Card has been partly updated in April 2005.
See sections Occupational Exposure Limits, EU classification, Emergency Response. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations