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PYRIDINE
ICSC: 0323
Peer-Review Status: 04.12.2000 Validated
Azine
Azabenzene 
CAS #: 110-86-1 RTECS #: UR8400000
UN #: 1282
EC #: 613-002-00-7
EINECS #: 203-809-9
 		    Formula: C5H5N
Molecular mass: 79.1

TYPES OF
HAZARD /
EXPOSURE 		ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Highly flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames, NO sparks and NO smoking.  Use water in large amounts, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE      
Inhalation Cough. Dizziness. Headache. Nausea. Shortness of breath. Unconciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Burning sensation. Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety spectacles or face shield.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Diarrhoea. Vomiting. Weakness. Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
 		PACKAGING & LABELLING
Personal protection: self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
Symbol: F, Xn; R: 11-20/21/22; S: (2)-26-28 
UN Classification
UN Hazard Class: 3; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-98.
NFPA Code: H2; F3; R0.  		Fireproof. Separated from strong oxidants and strong acids. Cool. Dry. Well closed. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
Decomposes on burning. This produces toxic fumes of of nitrogen oxides and hydrogen cyanide. The substance is a weak base. Reacts violently with strong oxidants and strong acids. 

Occupational exposure limits
TLV: 1ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2005).
MAK: Carcinogen category: 3B; Skin absorption (H); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system and gastrointestinal tract. Exposure far above the OEL could cause lowering of consciousness. 

Effects of long-term or repeated exposure
The substance may have effects on the central nervous system, liver and kidneys. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 115°C
Melting point: -42°C
Relative density (water = 1): 0.98
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 2.0
Relative vapour density (air = 1): 2.73
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.03
Flash point: 20°C c.c.
Auto-ignition temperature: 482°C
Explosive limits, vol% in air: 1.8-12.4
Octanol/water partition coefficient as log Pow: 0.65   		The substance is harmful to aquatic organisms. 

NOTES
Pyridine can normally be detected by odour at levels well below the TLV.
However, perception of the odour may decline quickly.
Depending on the degree of exposure, periodic medical examination is indicated.
Card has been partially updated in January 2008: see Ingestion First Aid. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety 		WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information. 
    See Also:
       Toxicological Abbreviations
       Pyridine  (IARC Summary & Evaluation, Volume 77, 2000)