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PHTHALIC ANHYDRIDE
ICSC: 0315
Peer-Review Status: 05.06.2003 Validated
1,2-Benzenedicarboxylic acid anhydride
Phthalic acid anhydride
1,3-Isobenzofurandione 
CAS #: 85-44-9 RTECS #: TI3150000
EC #: 607-009-00-4
EINECS #: 201-607-5
    Formula: C8H4O3 / C6H4(CO)2O
Molecular mass: 148.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames.  Use water spray, foam, dry powder, carbon dioxide. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent deposition of dust.   
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!   
Inhalation Cough. Sore throat. Wheezing.  Use local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer for medical attention. 
Skin Redness. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: Xn; R: 22-37/38-41-42/43; S: (2)-23-24/25-26-37/39-46 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F1; R0.  Separated from combustible substances, reducing agents, strong oxidants, strong bases, strong acids and food and feedstuffs. See Chemical Dangers. Ventilation along the floor. Dry. Well closed. 

IMPORTANT DATA
Physical State; Appearance
WHITE LUSTROUS CRYSTALS WITH CHARACTERISTIC ODOUR. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
Decomposes on contact with hot water. This produces phthalic acid. Reacts with strong oxidants, strong acids, strong bases and reducing agents. Reacts violently with copper oxide and sodium nitrite on heating. This generates explosion hazard. Attacks many metals in the presence of water. 

Occupational exposure limits
MAK: Sensitization of respiratory tract (SA); (DFG 2002). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered. 

Effects of short-term exposure
The substance is severely irritating to the eyes, skin and respiratory tract. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 284°C (sublimes)
Melting point: 131°C
Density: 1.53 g/cm³
Solubility in water: slow reaction
Vapour pressure, Pa at 20°C: <0.3
Relative vapour density (air = 1): 5.1
Flash point: 152°C c.c.
Auto-ignition temperature: 570°C
Explosive limits, vol% in air: 1.7-10.4
Octanol/water partition coefficient as log Pow: 1.6  
 

NOTES
The substance may be transported in molten state.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.
For materials containing more than 0.05% of maleic anhydride the UN number is 2214, hazard class 8, packaging group III and the Transport Emergency Card is TEC (R)-80S2214.
Do NOT take working clothes home.
Card has been partly updated in October 2005.
See section Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Phthalic anhydride (SIDS)