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MORPHOLINEICSC: 0302
Tetrahydro-1,4-oxazine
Diethylene oximide
November 2000
CAS #: 110-91-8
UN #: 2054
EC Number: 203-815-1

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Flammable. Gives off irritating or toxic fumes (or gases) in a fire.  Above 35°C explosive vapour/air mixtures may be formed.  NO open flames, NO sparks and NO smoking.  Above 35°C use a closed system, ventilation and explosion-proof electrical equipment.  Use water spray, powder, alcohol-resistant foam, carbon dioxide.  In case of fire: keep drums, etc., cool by spraying with water. 

 PREVENT GENERATION OF MISTS! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS PREVENTION FIRST AID
Inhalation Burning sensation. Cough. Laboured breathing. Shortness of breath. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. See Notes. 
Skin MAY BE ABSORBED! Redness. Pain. Skin burns. Blisters.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain. Blurred vision. Severe deep burns.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Burning sensation. Cough. Diarrhoea. Nausea. Shock or collapse. Vomiting.  Do not eat, drink, or smoke during work.  Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

 

Transportation
UN Classification
UN Hazard Class: 8; UN Subsidiary Risks: 3; UN Pack Group: I 

STORAGE
Fireproof. Separated from strong oxidants and acids. Dry. 
PACKAGING
 
MORPHOLINE ICSC: 0302
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS HYGROSCOPIC LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on burning. This produces toxic fumes of nitrogen oxides and carbon monoxide. The substance is a medium strong base. Reacts with strong oxidants. This generates fire hazard. Attacks plastics, rubber and coatings. Unstable if stored in copper or zinc containers. 

Formula: C4H9NO
Molecular mass: 87.1
Boiling point: 129°C
Melting point: -5°C
Relative density (water = 1): 1.0
Solubility in water: miscible
Vapour pressure, kPa at 20°C: 1.06
Relative vapour density (air = 1): 3.00
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 35°C c.c.
Auto-ignition temperature: 310°C
Explosive limits, vol% in air: 1.4-11.2
Octanol/water partition coefficient as log Pow: -0.86  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
The substance may have effects on the liver and kidneys. 


OCCUPATIONAL EXPOSURE LIMITS
TLV: 20 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen).
MAK: 36 mg/m3, 10 ppm; peak limitation category: I(2); pregnancy risk group: D.
EU-OEL: 36 mg/m3, 10 ppm as TWA; 72 mg/m3, 20 ppm as STEL 

ENVIRONMENT
 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Immediate administration of an appropriate inhalation therapy by a doctor, or by an authorized person, should be considered. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: C; R: 10-20/21/22-34; S: (1/2)-23-36-45 

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    See Also:
       Toxicological Abbreviations
       Morpholine (EHC 179, 1996)
       Morpholine (HSG 92, 1995)
       Morpholine  (IARC Summary & Evaluation, Volume 47, 1989)
       Morpholine  (IARC Summary & Evaluation, Volume 71, 1999)