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HEXAMETHYLENE DIISOCYANATE
ICSC: 0278
Peer-Review Status: 20.09.1993 Validated
HMDI
1,6-Hexamethylene diisocyanate
1,6-Diisocyanatohexane 
CAS #: 822-06-0 RTECS #: MO1740000
UN #: 2281
EC #: 615-011-00-1
EINECS #: 212-485-8
    Formula: C8H12N2O2 / OCN-(CH2)6-NCO
Molecular mass: 168.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT GENERATION OF MISTS! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Burning sensation. Cough. Laboured breathing. Shortness of breath. Sore throat.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Skin burns. Blisters.  Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness. Pain. Swelling of the eyelids.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion   Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Unbreakable packaging.
Put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs. 
EC Classification
Symbol: T; R: 23-36/37/38-42/43; S: (1/2)-26-28-38-45 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT1-II.  Separated from incompatible materials and food and feedstuffs. See Chemical Dangers. Cool. Dry. Keep in the dark. Ventilation along the floor. 

IMPORTANT DATA
Physical State; Appearance
CLEAR COLOURLESS LIQUID WITH PUNGENT ODOUR. 

Physical dangers
 

Chemical dangers
The substance polymerizes under the influence of temperatures above 93°C. On combustion, forms toxic and corrosive fumes including nitrogen oxides and hydrogen cyanide (see ICSC 0492). Decomposes on contact with water. This produces amine and polyureas. Reacts violently with acids, alcohols, amines, bases and oxidants. This generates fire and explosion hazard. Attacks copper. 

Occupational exposure limits
TLV: 0.005ppm as TWA; (ACGIH 2004).
MAK: 0.005 ppm, 0.035 mg/m³; Peak limitation category: I(1); Pregnancy risk group: D; Sensitization of respiratory tract and skin (SAH); (DFG 2006). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol or vapour and through the skin. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause respiratory sensitization. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 255°C
Melting point: -67°C
Relative density (water = 1): 1.05
Solubility in water: reaction
Vapour pressure, Pa at 25°C: 7
Relative vapour density (air = 1): 5.8
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 140°C o.c.
Auto-ignition temperature: 454°C
Explosive limits, vol% in air: 0.9-9.5
Octanol/water partition coefficient as log Pow: 1.08  
 

NOTES
Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.
Workers exposed to this compound may be sensitized to other isocyanates (asthma).
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home.
Desmodur H and Desmodur N are trade names.
Card has been partly updated in October 2005.
See sections Occupational Exposure Limits, Emergency Response.
Card has been partially updated in July 2007: see Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Hexamethylene diisocyanate  (SIDS)