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ACETIC ANHYDRIDE
ICSC: 0209
Peer-Review Status: 04.04.2006 Validated
Acetic acid, anhydride
Acetic oxide
Ethanoic anhydride
Acetyl oxide 
CAS #: 108-24-7 RTECS #: AK1925000
UN #: 1715
EC #: 607-008-00-9
EINECS #: 203-564-8
    Formula: C4H6O3/(CH3CO)2O
Molecular mass: 102.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Flammable.  NO open flames, NO sparks and NO smoking.  Use alcohol-resistant foam, powder, carbon dioxide. See Notes. 
EXPLOSION Above 49°C explosive vapour/air mixtures may be formed.  Above 49°C use a closed system, ventilation and explosion-proof electrical equipment.  In case of fire: keep drums, etc., cool by spraying with water. NO direct contact with water. 
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Laboured breathing. Shortness of breath. Sore throat.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention. 
Skin Redness. Skin burns. Pain. Blisters. Symptoms may be delayed.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Watering of the eyes. Redness. Pain. Burns.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Burning sensation. Shock or collapse.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Consult an expert! Personal protection: chemical protection suit, face shield and filter respirator for acid gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: C; R: 10-20/22-34; S: (1/2)-26-36/37/39-45 
UN Classification
UN Hazard Class: 8; UN Subsidiary Risks: 3; UN Pack Group: II 
GHS Classification
Signal: Danger
Flammable liquid and vapour
Harmful if swallowed
Causes severe skin burns and eye damage
Causes serious eye damage 
flam;flameexcl mark;warncorr

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-80S1715.
NFPA Code: H2; F2; R1; W. 
Fireproof. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Dry. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH PUNGENT ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on burning. This produces toxic gases and toxic fumes including acetic acid fumes. Reacts violently with alcohols, amines, oxidants, strong bases and water. Attacks many metals in the presence of water or when dry. 

Occupational exposure limits
TLV: 5ppm as TWA; (ACGIH 2006).
MAK: 5 ppm, 21 mg/m³; Peak limitation category: I(1); Pregnancy risk group: D; (DFG 2007). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
Lachrymation. The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause asthma-like reactions. 

Effects of long-term or repeated exposure
Inhalation may cause asthma-like reactions (RADS). 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 139°C
Melting point: -73°C
Relative density (water = 1): 1.08
Solubility in water: reaction
Vapour pressure, kPa at 20°C: 0.5
Relative vapour density (air = 1): 3.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01
Flash point: 49°C c.c.
Auto-ignition temperature: 316°C
Explosive limits, vol% in air: 2.7-10.3
Octanol/water partition coefficient as log Pow: -0.27  
 

NOTES
Forms acetic acid when mixed with water.
Major fires must be extinguished with large amounts of water from a distance.
Card has been partially updated in July 2007: see Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Acetic anhydride (SIDS)