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PROPYLENE OXIDEICSC: 0192
1,2-Epoxypropane
Methyloxirane
Methyl ethylene oxide
Propene oxide
November 2009
CAS #: 75-56-9
UN #: 1280
EC Number: 200-879-2

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Extremely flammable. Heating will cause rise in pressure with risk of bursting.  Vapour/air mixtures are explosive.  NO open flames, NO sparks and NO smoking.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.  Use alcohol-resistant foam, foam, water spray.  In case of fire: keep drums, etc., cool by spraying with water. 

 STRICT HYGIENE!  
  SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Seek medical attention if you feel unwell. 
Skin Redness.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear safety goggles or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion Sore throat.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention if breathing difficulties and/or fever develop. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable dry containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

flam;flameexcl mark;warncancer;health haz
DANGER
Extremely flammable liquid and vapour
Harmful if swallowed, in contact with skin or if inhaled
Causes skin and eye irritation
Suspected of causing genetic defects
Suspected of causing cancer
May cause respiratory irritation
May be harmful if swallowed and enters airways 

Transportation
UN Classification
UN Hazard Class: 3; UN Pack Group: I 

STORAGE
Fireproof. Separated from acids, bases and strong oxidants. Dry. Cool. Well closed. Keep in the dark. 
PACKAGING
Unbreakable packaging.
Put breakable packaging into closed unbreakable container. 
PROPYLENE OXIDE ICSC: 0192
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
VERY VOLATILE COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated. 

Chemical dangers
The substance may violently polymerize under the influence of bases, acids and metal chlorides. This generates fire and explosion hazard. Reacts violently with chlorine, ammonia, strong oxidants and acids. This generates fire or explosion hazard. 

Formula: C3H6O / CH3CHCH2O
Molecular mass: 58.1
Boiling point: 34°C
Melting point: -112°C
Relative density (water = 1): 0.83
Solubility in water, g/100ml at 20°C: 40
Vapour pressure, kPa at 20°C: 59
Relative vapour density (air = 1): 2.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.6
Flash point: -37°C c.c.
Auto-ignition temperature: 430°C
Explosive limits, vol% in air: 1.9-36.3
Octanol/water partition coefficient as log Pow: 0.03
Viscosity: 0.34 mm²/s at 25°C 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. 

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. This substance is possibly carcinogenic to humans. 


OCCUPATIONAL EXPOSURE LIMITS
TLV: 2 ppm as TWA; (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: 4.8 mg/m3, 2 ppm; peak limitation category: I(2); sensitization of skin (SH); carcinogen category: 4; pregnancy risk group: C 

ENVIRONMENT
 

NOTES
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: F+, T; R: 45-46-12-20/21/22-36/37/38; S: 53-45; Note: E 

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    See Also:
       Toxicological Abbreviations
       Propylene oxide (EHC 56, 1985)
       Propylene oxide (HSG 15, 1988)
       PROPYLENE OXIDE (JECFA Evaluation)
       Propylene Oxide (IARC Summary & Evaluation, Volume 60, 1994)