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PROPYLENE OXIDE
ICSC: 0192
Peer-Review Status: 24.11.2009 Validated
1,2-Epoxypropane
Methyloxirane
Methyl ethylene oxide
Propene oxide 
CAS #: 75-56-9 RTECS #: TZ2975000
UN #: 1280
EC #: 603-055-00-4
EINECS #: 200-879-2
    Formula: C3H6O / CH3CHCH2O
Molecular mass: 58.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Extremely flammable. Heating will cause rise in pressure with risk of bursting.  NO open flames, NO sparks and NO smoking.  Use alcohol-resistant foam, foam, water spray. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   STRICT HYGIENE!   
Inhalation Cough. Sore throat.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Seek medical attention if you feel unwell. 
Skin Redness.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear safety goggles or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion Sore throat.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer for medical attention if breathing difficulties and/or fever develop. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Remove all ignition sources. Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable dry containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.  Unbreakable packaging.
Put breakable packaging into closed unbreakable container. 
EC Classification
Symbol: F+, T; R: 45-46-12-20/21/22-36/37/38; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 3; UN Pack Group: I 
GHS Classification
Signal: Danger
Extremely flammable liquid and vapour
Harmful if swallowed
Harmful in contact with skin
Harmful if inhaled (vapour)
Causes skin and eye irritation
Suspected of causing genetic defects
Suspected of causing cancer
May cause respiratory irritation
May be harmful if swallowed and enters airways 
flam;flameexcl mark;warncancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F4; R2.  Fireproof. Separated from acids, bases and strong oxidants. Dry. Cool. Well closed. Keep in the dark. 

IMPORTANT DATA
Physical State; Appearance
VERY VOLATILE COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated. 

Chemical dangers
The substance may violently polymerize under the influence of bases, acids and metal chlorides. This generates fire and explosion hazard. Reacts violently with chlorine, ammonia, strong oxidants and acids. This generates fire or explosion hazard. 

Occupational exposure limits
TLV: 2ppm as TWA; (SEN); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2009).
MAK: Carcinogen category: 2; Skin absorption (H); (DFG 2009).
EU OEL:. 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. This substance is possibly carcinogenic to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 34°C
Melting point: -112°C
Relative density (water = 1): 0.83
Solubility in water, g/100ml at 20°C: 40
Vapour pressure, kPa at 20°C: 59
Relative vapour density (air = 1): 2.0
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.6
Flash point: -37°C c.c.
Auto-ignition temperature: 430°C
Explosive limits, vol% in air: 1.9-36.3
Octanol/water partition coefficient as log Pow: 0.03
Viscosity: 0.34 mm²/s at 25°C 
 

NOTES
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Propylene oxide (EHC 56, 1985)
       Propylene oxide (HSG 15, 1988)
       PROPYLENE OXIDE (JECFA Evaluation)
       Propylene Oxide (IARC Summary & Evaluation, Volume 60, 1994)