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PHOSPHAMIDON
ICSC: 0189
Peer-Review Status: 20.10.2005 Validated
2-Chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate
2-Chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl phosphate
Dimethyl phosphate ester 2-chloro-N,N-diethyl-3-hydroxycrotonamide
O,O-Dimethyl-O-(2-chloro-2-diethylcarbamoyl-1-methylvinyl) phosphate 
CAS #: 13171-21-6 RTECS #: TC2800000
UN #: 3018
EC #: 015-022-00-6
EINECS #: 236-116-5
    Formula: C10H19ClNO5P
Molecular mass: 299.7

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.    In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE   STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Sweating. Muscle twitching. Pupillary constriction, muscle cramp, excessive salivation. Diarrhoea. Dizziness. Laboured breathing. Vomiting. Convulsions. Unconciousness. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. See Notes. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable non-metallic containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs.
Severe marine pollutant. 
EC Classification
Symbol: T+, N; R: 24-28-68-50/53; S: (1/2)-23-36/37-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT6-II.  Store in an area without drain or sewer access. Well closed. Keep in a well-ventilated room. Separated from bases and food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-YELLOW OILY LIQUID. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces highly toxic fumes including phosphorus oxides, hydrogen chloride and nitrogen oxides. Reacts with bases (hydrolysis). Attacks metals such as iron, tin and aluminium. 

Occupational exposure limits
TLV: BEI issued; (ACGIH 2005).
MAK (not established):. 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying. 

Effects of short-term exposure
The substance is irritating to the eyes. The substance may cause effects on the nervous system. This may result in convulsions, respiratory depression and death. Exposure at high levels could cause death. Cholinesterase inhibition. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point at 0.2kPa: 162°C
Melting point: -45°C
Relative density (water = 1): 1.2
Solubility in water: miscible
Vapour pressure, Pa at 20°C: 0.0033
Octanol/water partition coefficient as log Pow: 0.8  
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds and bees. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Commercial product is a mixture of isomers.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home.
Pillarcron, Dimecron and Phosron are trade names. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Phosphamidon (PIM 454)
       Phosphamidon (FAO Meeting Report PL/1965/10/1)
       Phosphamidon (FAO/PL:CP/15)
       Phosphamidon (FAO/PL:1968/M/9/1)
       Phosphamidon (FAO/PL:1969/M/17/1)
       Phosphamidon (WHO Pesticide Residues Series 2)
       Phosphamidon (WHO Pesticide Residues Series 4)
       Phosphamidon (Pesticide residues in food: 1982 evaluations)
       Phosphamidon (Pesticide residues in food: 1986 evaluations Part II Toxicology)