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MALATHION
ICSC: 0172
Peer-Review Status: 19.10.2005 Validated
Diethyl(dimethoxythiophosphorylthio)succinate
S-1,2-bis(Ethoxycarbonyl)ethyl O,O-dimethylphosphorodithioate
Butanedioic acid, {(dimethoxyphosphinothioyl)thio}-, diethyl ester 
CAS #: 121-75-5 RTECS #: WM8400000
UN #: 3082
EC #: 015-041-00-X
EINECS #: 204-497-7
    Formula: C10H19O6PS2
Molecular mass: 330.4

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use foam. Use powder. Use carbon dioxide. 
EXPLOSION      
 
EXPOSURE   STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!   
Inhalation Dizziness. Pupillary constriction. Muscle cramps. Excessive salivation. Sweating. Laboured breathing. Unconciousness. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer for medical attention. 
Skin   Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes   Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Diarrhoea. Nausea. Vomiting. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. See Chemical Dangers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
Symbol: Xn, N; R: 22-50/53; S: (2)-24-60-61 
UN Classification
UN Hazard Class: 9; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-90GM6-III.  Store in an area without drain or sewer access. Separated from strong oxidants and food and feedstuffs. Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
YELLOW-TO-BROWN LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including phosphorus oxides and sulfur oxides. Reacts violently with strong oxidants. Attacks iron, some other metals, some forms of plastic and rubber. Decomposes on heating. This produces the more toxic isomalathion. 

Occupational exposure limits
TLV: 1mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2005).
MAK (inhalable fraction): 15 mg/m³; Peak limitation category: II(4); Pregnancy risk group: D; (DFG 2005). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The substance may cause effects on the central nervous system. This may result in convulsions and respiratory depression. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point at 0.093kPa: 156-157°C
Melting point: 3°C
Relative density (water = 1): 1.2
Solubility in water, mg/l: 145
Vapour pressure at 30°C: negligible
Relative vapour density (air = 1): 11.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 163°C c.c.
Octanol/water partition coefficient as log Pow: 2.89  
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to bees. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvents also consult the ICSCs of these materials.
Carrier solvents used in commercial formulations may change physical and toxicological properties. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Malathion (FAO Meeting Report PL/1965/10/1)
       Malathion (FAO/PL:CP/15)
       Malathion (FAO/PL:1967/M/11/1)
       Malathion (JMPR Evaluations 2003 Part II Toxicological)
       Malathion (FAO/PL:1968/M/9/1)
       Malathion (FAO/PL:1969/M/17/1)
       Malathion (AGP:1970/M/12/1)
       Malathion (WHO Pesticide Residues Series 3)
       Malathion (WHO Pesticide Residues Series 5)
       Malathion (Pesticide residues in food: 1977 evaluations)
       Malathion (Pesticide residues in food: 1984 evaluations)
       Malathion (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental)
       Malathion (IARC Summary & Evaluation, Volume 30, 1983)