MALATHION (ICSC)

MALATHION	ICSC: 0172

Date of Peer Review: October 2005

Diethyl(dimethoxythiophosphorylthio)succinate
S-1,2-bis(Ethoxycarbonyl)ethyl O,O-dimethylphosphorodithioate
Butanedioic acid, {(dimethoxyphosphinothioyl)thio}-, diethyl ester

CAS #

121-75-5

C₁₀H₁₉O₆PS₂

RTECS #

WM8400000

Molecular mass: 330.4

UN #

3082

EC Index #

015-041-00-X

TYPES OF HAZARD / EXPOSURE	ACUTE HAZARDS / SYMPTOMS	PREVENTION	FIRST AID / FIRE FIGHTING
FIRE	Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Foam. Powder. Carbon dioxide.
EXPLOSION

EXPOSURE		STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!
Inhalation	Dizziness. Pupillary constriction. Muscle cramp. Excessive salivation. Sweating. Laboured breathing. Unconsciousness. Symptoms may be delayed (see Notes).	Ventilation, local exhaust, or breathing protection.	Fresh air, rest. Half-upright position. Refer for medical attention.
Skin		Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes		Safety goggles or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion	Abdominal cramps. Diarrhoea. Nausea. Vomiting. (Further see Inhalation).	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention.

SPILLAGE DISPOSAL

PACKAGING & LABELLING

Personal protection: filter respirator for organic gases and vapours. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. See Chemical Dangers. Absorb remaining liquid in sand or inert absorbent and remove to safe place.

Do not transport with food and feedstuffs. Marine pollutant.
EU Classification
Symbol: Xn, N
R: 22-50/53
S: (2-)-24-60-61
UN Classification
UN Hazard Class: 9
UN Pack Group: III

EMERGENCY RESPONSE

STORAGE

Transport Emergency Card: TEC (R)-90GM6-III.

Store in an area without drain or sewer access. Separated from strong oxidants, food and feedstuffs. Keep in a well-ventilated room.

IPCS
International
Programme on
Chemical Safety

Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities Š IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK

MALATHION

ICSC: 0172

IMPORTANT DATA

PHYSICAL STATE; APPEARANCE:
YELLOW TO BROWN LIQUID, WITH CHARACTERISTIC ODOUR.

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including phosphorus oxides and sulfur oxides. Reacts violently with strong oxidants. Attacks iron and some other metals, some forms of plastic and rubber. May form the more toxic isomalathion on heating.

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 1 mg/mł as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2005).
MAK: (Inhalable fraction) 15 mg/mł; Peak limitation category: II(4); Pregnancy risk group: D; (DFG 2005).

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

INHALATION RISK:
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the central nervous system, resulting in convulsions and respiratory depression. The effects may be delayed. Medical observation is indicated.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact may cause skin sensitization. Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.

PHYSICAL PROPERTIES

Boiling point at 0.093 kPa: 156-157°C
Melting point: 3°C
Relative density (water = 1): 1.2
Solubility in water: 145 mg/l
Vapour pressure, Pa at 30°C: negligible
Relative vapour density (air = 1): 11.4

Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 163°C c.c.
Octanol/water partition coefficient as log Pow: 2.89

ENVIRONMENTAL DATA

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment; special attention should be given to honey bees. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.

NOTES

Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. If the substance is formulated with solvents also consult the ICSCs of these materials. Carrier solvents used in commercial formulations may change physical and toxicological properties.

ADDITIONAL INFORMATION

LEGAL NOTICE

Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information

Š IPCS, CEC 2005

    See Also:
       Toxicological Abbreviations
       Malathion (PDS)
       Malathion (FAO Meeting Report PL/1965/10/1)
       Malathion (FAO/PL:CP/15)
       Malathion (FAO/PL:1967/M/11/1)
       Malathion (JMPR Evaluations 2003 Part II Toxicological)
       Malathion (FAO/PL:1968/M/9/1)
       Malathion (FAO/PL:1969/M/17/1)
       Malathion (AGP:1970/M/12/1)
       Malathion (WHO Pesticide Residues Series 3)
       Malathion (WHO Pesticide Residues Series 5)
       Malathion (Pesticide residues in food: 1977 evaluations)
       Malathion (Pesticide residues in food: 1984 evaluations)
       Malathion (Pesticide residues in food: 1997 evaluations Part II Toxicological & Environmental)
       Malathion (IARC Summary & Evaluation, Volume 30, 1983)