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ISOPHORONEICSC: 0169
1,1,3-Trimethyl-3-cyclohexene-5-one
3,5,5-Trimethylcyclohex-2-enone
Isoacetophorone
October 2000
CAS #: 78-59-1
EC Number: 201-126-0

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible.  Above 84°C explosive vapour/air mixtures may be formed.  NO open flames.  Above 84°C use a closed system and ventilation.  Use water spray, powder, foam, carbon dioxide.   

 PREVENT GENERATION OF MISTS!  
  SYMPTOMS PREVENTION FIRST AID
Inhalation Burning sensation. Sore throat. Cough. Dizziness. Headache. Nausea. Shortness of breath.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse and then wash skin with water and soap. 
Eyes Redness. Pain. Blurred vision.  Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Further see Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Do NOT induce vomiting. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

 

Transportation
UN Classification
 

STORAGE
Separated from strong oxidants, strong bases and amines. 
PACKAGING
 
ISOPHORONE ICSC: 0169
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Reacts with strong oxidants, strong bases and amines. 

Formula: C9H14O
Molecular mass: 138.2
Boiling point: 215°C
Melting point: -8°C
Relative density (water = 1): 0.92
Solubility in water, g/100ml at 25°C: 1.2
Vapour pressure, Pa at 20°C: 40
Relative vapour density (air = 1): 4.8
Flash point: 84°C c.c.
Auto-ignition temperature: 460°C
Explosive limits, vol% in air: 0.8-3.8
Octanol/water partition coefficient as log Pow: 1.67  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Effects of short-term exposure
The substance and the vapour are irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
 


OCCUPATIONAL EXPOSURE LIMITS
TLV: 5 ppm as STEL; A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: 11 mg/m3, 2 ppm; peak limitation category: I(2); carcinogen category: 3B; pregnancy risk group: C 

ENVIRONMENT
 

NOTES
The occupational exposure limit value should not be exceeded during any part of the working exposure. 

ADDITIONAL INFORMATION
  EC Classification
Symbol: Xn; R: 21/22-36/37-40; S: (2)-13-23-36/37/39-46 

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    See Also:
       Toxicological Abbreviations
       Isophorone (EHC 174, 1995)
       Isophorone (HSG 91, 1995)
       ISOPHORONE (JECFA Evaluation)