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DIMETHYL SULFATE
ICSC: 0148
Peer-Review Status: 12.11.2008 Validated
Sulfuric acid dimethyl ester
Dimethyl monosulfate
DMS 
CAS #: 77-78-1 RTECS #: WS8225000
UN #: 1595
EC #: 016-023-00-4
EINECS #: 201-058-1
    Formula: C2H6O4S / (CH3O)2SO2
Molecular mass: 126.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use powder, foam, carbon dioxide, water spray. 
EXPLOSION Above 83°C explosive vapour/air mixtures may be formed.  Above 83°C use a closed system and ventilation.   
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Sore throat. Burning sensation. Shortness of breath. Headache. Symptoms may be delayed. See Notes.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain. Blisters. Skin burns.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer immediately for medical attention. 
Eyes Redness. Pain. Burns. Permanent loss of vision.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Burns in mouth and throat. Burning sensation in the throat and chest. Abdominal cramps. Vomiting. Convulsions. Shock or collapse. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.  Unbreakable packaging.
Put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs. 
EC Classification
Symbol: T+; R: 45-25-26-34-43-68; S: 53-45; Note: E 
UN Classification
UN Hazard Class: 6.1; UN Subsidiary Risks: 8; UN Pack Group: I 
GHS Classification
Signal: Danger
Combustible liquid
Fatal if inhaled vapour
Toxic if swallowed
Causes severe skin burns and eye damage
May cause allergic skin reaction
Suspected of causing genetic defects
May cause cancer
Causes damage to liver, kidneys and lungs
Causes damage to the lungs through prolonged or repeated exposure
Harmful to aquatic life 
corrskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S1595 or 61GTC1-I.
NFPA Code: H4; F2; R1. 
Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Dry. Well closed. Ventilation along the floor. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS OILY LIQUID. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including sulfur oxides. The solution is a medium strong acid. Reacts with water. This produces sulfuric acid. This generates heat. Reacts violently with concentrated aqueous ammonia, bases, acids and strong oxidants. This generates fire and explosion hazard. 

Occupational exposure limits
TLV: 0.1ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2008).
MAK: Carcinogen category: 2; Skin absorption (H); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema. See Notes. The substance may cause effects on the liver and kidneys. This may result in impaired functions. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Repeated or prolonged inhalation of the vapour may cause effects on the lungs. This substance is probably carcinogenic to humans. Repeated or prolonged contact may cause skin sensitization. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 188°C
Melting point: -32°C
Relative density (water = 1): 1.3
Solubility in water, g/100ml at 18°C: 2.8
Vapour pressure, Pa at 20°C: 65
Relative vapour density (air = 1): 4.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 83°C c.c.
Auto-ignition temperature: 470°C
Explosive limits, vol% in air: 3.6-23.3
Octanol/water partition coefficient as log Pow: 0.16  
The substance is harmful to aquatic organisms. 

NOTES
Commercial dimethyl sulfate may contain trace amounts of sulfuric acid.
Depending on the degree of exposure, periodic medical examination is suggested.
The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered.
There is no odour warning even when toxic concentrations are present.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Dimethyl sulfate (EHC 48, 1985)
       Dimethyl sulfate (HSG 29, 1989)
       Dimethyl Sulfate (IARC Summary & Evaluation, Volume 71, 1999)