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ACRYLAMIDE
ICSC: 0091
Peer-Review Status: 04.10.2013 Validated
2-Propene amide
Acrylic acid amide
Vinyl amide 
CAS #: 79-06-1 RTECS #: AS3325000
UN #: 2074
EC #: 616-003-00-0
EINECS #: 201-173-7
    Formula: C3H5NO / CH2=CH-CONH2
Molecular mass: 71.1

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Prevent deposition of dust.   
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Sore throat. Weakness.  Use closed system or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . Wear protective gloves when administering first aid. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Weakness. See Notes.  Do not eat, drink, or smoke during work.  Rinse mouth. Give one or two glasses of water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Special material.
Do not transport with food and feedstuffs.
Special packaging required. 
EC Classification
Symbol: T; R: 45-46-20/21-25-36/38-43-48/23/24/25-62; S: 53-45; Note: D, E 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Toxic if swallowed
Harmful in contact with skin or if inhaled
Causes skin irritation
Causes serious eye irritation
May cause an allergic skin reaction
May cause genetic defects
May cause cancer
Suspected of damaging fertility or the unborn child
Causes damage to nervous system
Causes damage to the nervous system through prolonged or repeated exposure 
skull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H2; F2; R2.  Separated from incompatible materials. See Chemical Dangers. Cool. Keep in the dark. Well closed. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
WHITE CRYSTALS. 

Physical dangers
 

Chemical dangers
The substance polymerizes violently due to heating above 85°C or under the influence of light and oxidants. It reacts with strong bases and strong oxidants. Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides. 

Occupational exposure limits
TLV: 0.03mg/m³ as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2013).
MAK: Carcinogen category: 2; Germ cell mutagen group: 2; Skin absorption (H); Sensitization of skin (SH); (DFG 2013). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. The effects may be delayed. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system. This may result in peripheral nerve damage. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. May cause toxicity to human reproduction or development. Repeated or prolonged contact with skin may cause dermatitis. See Notes. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 84.5°C
Density: 1.13 g/cm³
Solubility in water, g/100ml at 25°C: 204 (very good)
Vapour pressure, Pa at 25°C: 0.9
Relative vapour density (air = 1): 2.45
Flash point: 138°C c.c.
Auto-ignition temperature: 424°C
Octanol/water partition coefficient as log Pow: -0.78  
This substance may be hazardous to the environment. Special attention should be given to fish. 

NOTES
A severe intoxication is only likely after ingestion of large amounts. The following effects were reported: hallucinations, hypotension and convulsions.
Depending on the degree of exposure, periodic medical examination is suggested.
Do NOT take working clothes home.
Long term exposure can cause skin peeling, rashes and acne-like dermatitis.
Damage to the peripheral nervous system may cause reversible effects like unsteady gait, impaired speech, tingling sensations, incoordination, tremors of the hands and numbness of extremities.
Other UN number for acrylamide solution is 3426, hazard class 6.1, packing group III 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Acrylamide (EHC 49, 1985)
       Acrylamide (HSG 45, 1991)
       Acrylamide (WHO Food Additives Series 55)
       ACRYLAMIDE (JECFA Evaluation)
       Acrylamide (PIM 652)
       Acrylamide (IARC Summary & Evaluation, Volume 60, 1994)