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ACRYLAMIDEICSC: 0091
October 2013
CAS #: 79-06-12-Propene amide
Acrylic acid amide
Vinyl amide
UN #: 2074
EINECS #: 201-173-7

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  Finely dispersed particles form explosive mixtures in air.  NO open flames.  Prevent deposition of dust.  Use water spray, powder, alcohol-resistant foam, carbon dioxide.   

 PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR! 
  SYMPTOMS ACUTE HAZARDS FIRST AID
Inhalation Cough. Sore throat. Weakness.  Use closed system or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . Wear protective gloves when administering first aid. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Weakness. See Notes.  Do not eat, drink, or smoke during work.  Rinse mouth. Give one or two glasses of water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered sealable containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

skull;toxiccancer;health haz
DANGER
Toxic if swallowed
Harmful in contact with skin or if inhaled
Causes skin irritation
Causes serious eye irritation
May cause an allergic skin reaction
May cause genetic defects
May cause cancer
Suspected of damaging fertility or the unborn child
Causes damage to nervous system
Causes damage to the nervous system through prolonged or repeated exposure 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 

STORAGE
Separated from incompatible materials. See Chemical Dangers. Cool. Keep in the dark. Well closed. Store in an area without drain or sewer access. 
PACKAGING
Special material.
Do not transport with food and feedstuffs.
Special packaging required. 
ACRYLAMIDE ICSC: 0091
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALS. 

Physical dangers
 

Chemical dangers
The substance polymerizes violently due to heating above 85°C or under the influence of light and oxidants. It reacts with strong bases and strong oxidants. Decomposes on burning. This produces toxic and corrosive fumes including nitrogen oxides. 

Formula: C3H5NO / CH2=CH-CONH2
Molecular mass: 71.1
Melting point: 84.5°C
Density: 1.13 g/cm³
Solubility in water, g/100ml at 25°C: 204 (very good)
Vapour pressure, Pa at 25°C: 0.9
Relative vapour density (air = 1): 2.45
Flash point: 138°C c.c.
Auto-ignition temperature: 424°C
Octanol/water partition coefficient as log Pow: -0.78  


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. The effects may be delayed. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the nervous system. This may result in peripheral nerve damage. This substance is probably carcinogenic to humans. May cause heritable genetic damage to human germ cells. May cause toxicity to human reproduction or development. Repeated or prolonged contact with skin may cause dermatitis. See Notes. 


Occupational exposure limits
TLV: 0.03 mg/m3, - ppm, as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: carcinogen category: 2; germ cell mutagen group: 2; sensitization of skin (SH); skin absorption (H) 

ENVIRONMENT
This substance may be hazardous to the environment. Special attention should be given to fish. 

NOTES
A severe intoxication is only likely after ingestion of large amounts. The following effects were reported: hallucinations, hypotension and convulsions.
Depending on the degree of exposure, periodic medical examination is suggested.
Do NOT take working clothes home.
Long term exposure can cause skin peeling, rashes and acne-like dermatitis.
Damage to the peripheral nervous system may cause reversible effects like unsteady gait, impaired speech, tingling sensations, incoordination, tremors of the hands and numbness of extremities.
Other UN number for acrylamide solution is 3426, hazard class 6.1, packing group III 

ADDITIONAL INFORMATION
  EC Classification
Symbol: T; R: 45-46-20/21-25-36/38-43-48/23/24/25-62; S: 53-45; Note: D, E 

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    See Also:
       Toxicological Abbreviations
       Acrylamide (EHC 49, 1985)
       Acrylamide (HSG 45, 1991)
       Acrylamide (WHO Food Additives Series 55)
       ACRYLAMIDE (JECFA Evaluation)
       Acrylamide (PIM 652)
       Acrylamide (IARC Summary & Evaluation, Volume 60, 1994)