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NITROBENZENE
ICSC: 0065
Peer-Review Status: 06.04.2006 Validated
 
CAS #: 98-95-3 RTECS #: DA6475000
UN #: 1662
EC #: 609-003-00-7
EINECS #: 202-716-0
    Formula: C6H5NO2
Molecular mass: 123.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, alcohol-resistant foam, dry powder, carbon dioxide. 
EXPLOSION Above 88°C explosive vapour/air mixtures may be formed. Risk of fire and explosion. See Chemical Dangers.  Above 88°C use a closed system and ventilation.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   AVOID ALL CONTACT!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Headache. Blue lips, fingernails and skin. Blue lips, fingernails and skin. Dizziness. Nausea. Weakness. Confusion. Convulsions. Unconciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes   Wear safety goggles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T, N; R: 23/24/25-40-48/23/24-51/53-62; S: (1/2)-28-36/37-45-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Harmful if swallowed
Toxic if inhaled (vapour)
Toxic in contact with skin
Suspected of causing cancer
Suspected of damaging fertility or the unborn child
May cause damage to blood cells
Harmful to aquatic life with long lasting effects 
skull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61S1662 or 61GT1-II.
NFPA Code: H3; F2; R1. 
Separated from combustible substances, reducing agents, strong oxidants, strong acids and food and feedstuffs. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
PALE YELLOW OILY LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
On combustion, forms toxic and corrosive fumes including nitrogen oxides. Reacts violently with strong oxidants and reducing agents. This generates fire and explosion hazard. Reacts violently with strong acids and nitrogen oxides. This generates explosion hazard. 

Occupational exposure limits
TLV: 1ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued; (ACGIH 2005).
MAK: Carcinogen category: 3B; Skin absorption (H); BAT issued; (DFG 2006).
EU OEL ( selected): 0.2ppm, 1mg/m³ as TWA;. 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The substance may cause effects on the blood. This may result in formation of methaemoglobin. Exposure could cause lowering of consciousness. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
The substance may have effects on the blood, spleen and liver. This substance is possibly carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 211°C
Melting point: 5°C
Relative density (water = 1): 1.2
Solubility in water, g/100ml: 0.2
Vapour pressure, Pa at 20°C: 20
Relative vapour density (air = 1): 4.2
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 88°C c.c.
Auto-ignition temperature: 480°C
Explosive limits, vol% in air: 1.8-40
Octanol/water partition coefficient as log Pow: 1.86  
The substance is harmful to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
Use of alcoholic beverages enhances the harmful effect.
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Do NOT take working clothes home.
Card has been partly updated in October 2006: see sections Occupational Exposure Limits.
Card has been partially updated in January 2008: see GHS classification. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Nitrobenzene (EHC 230, 2003)
       Nitrobenzene (IARC Summary & Evaluation, Volume 65, 1996)