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ANILINE
ICSC: 0011
Peer-Review Status: 11-04-2014 Validated
Benzeneamine
Aminobenzene
Phenylamine
CAS #: 62-53-3 RTECS #: BW6650000
UN #: 1547
EC #: 612-008-00-7
EINECS #: 200-539-3
    Formula: C6H7N / C6H5NH2
Molecular mass: 93.1

TYPES OF HAZARD
/ EXPOSURE
ACUTE HAZARDS / SYMPTOMS PREVENTION FIRST AID / FIRE-FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames. NO contact with oxidizing agents.  Use water spray, powder, foam, carbon dioxide. 
EXPLOSION Above 76°C explosive vapour/air mixtures may be formed.  Above 76°C use a closed system and ventilation.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS! STRICT HYGIENE! See Notes.   
Inhalation Blue lips, fingernails and skin. Headache. Dizziness. Nausea. Vomiting. Weakness. Laboured breathing. Convulsions.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Administration of oxygen may be needed. Refer immediately for medical attention. See Notes. 
Skin EASILY ABSORBED! Redness. Further see Inhalation.  Protective gloves. Protective clothing.  Administration of oxygen may be needed. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. See Notes. 
Eyes Redness. Pain. Corneal damage.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Administration of oxygen may be needed. Rinse mouth. Do NOT induce vomiting. Rest. Refer immediately for medical attention. See Notes. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T, N; R: 23/24/25-40-41-43-48/23/24/25-68-50; S: (1/2)-26-27-36/37/39-45-46-63-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: II 
GHS Classification
Signal: Danger
Toxic if swallowed, in contact with skin or if inhaled
Causes damage to red blood cells
Causes damage to the blood through prolonged or repeated exposure
Causes serious eye irritation
May cause an allergic skin reaction
Very toxic to aquatic life 
skull;toxiccancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H3; F2; R0.  Separated from strong oxidants, strong acids and food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS OILY LIQUID WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR OR LIGHT. 

Physical dangers
 

Chemical dangers
Decomposes above 190°C . This produces toxic and corrosive fumes of nitrogen oxides and ammonia and flammable vapours. Reacts with strong acids and strong oxidants. This generates fire and explosion hazard. Attacks copper and its alloys. 

Occupational exposure limits
TLV: 2ppm as TWA; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans); BEI issued; (ACGIH 2014).
MAK: 2 ppm, 7.7 mg/m³; Carcinogen category: 4; Peak limitation category: II(2); Pregnancy risk group: C; Skin absorption (H); Sensitization of skin (SH); BAT issued; (DFG 2014).
EU OEL: 0.5 ppm, 1.94 mg/m³ as TWA; 1 ppm, 3.87 mg/m³ as STEL; SCOEL recommendation available (SCOEL 2010). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin also as a vapour and by ingestion. 

Inhalation risk
A harmful contamination of the air will be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. 

Effects of short-term exposure
The substance is severely irritating to the eyes. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. See Notes. Exposure could cause haemolysis. This may result in haemolytic anaemia. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in haemolytic anaemia. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 184°C
Melting point: -6°C
Relative density (water = 1): 1.02
Solubility in water, g/100ml at 20°C: 3.4
Vapour pressure, Pa at 20°C: 40
Relative vapour density (air = 1): 3.2
Flash point: 76°C c.c.
Auto-ignition temperature: 630°C
Explosive limits, vol% in air: 1.2-11.0
Octanol/water partition coefficient as log Pow: 0.94  
The substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment. 

NOTES
In case of blue lips, fingernails or skin treatment with 100% oxygen may be needed; the appropriate means with instructions must be available.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Specific treatment with antidota like methylene blue can not be used for pregnant women and persons with a G6PD enzym deficiency. These people should avoid all contact.
The odour warning when the exposure limit value is exceeded is insufficient. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Aniline  (IARC Summary & Evaluation, Supplement7, 1987)
       Aniline (IARC Summary & Evaluation, Volume 4, 1974)