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PARATHION
ICSC: 0006
Peer-Review Status: 22.04.2004 Validated
O,O-Diethyl-O-(4-nitrophenyl)phosphorothioate
Phosphorothioic acid O,O-diethyl O-(4-nitrophenyl) ester
Ethyl parathion 
CAS #: 56-38-2 RTECS #: TF4550000
UN #: 3018
EC #: 015-034-00-1
EINECS #: 200-271-7
    Formula: (C2H5O)2PSOC6H4NO2
Molecular mass: 291.3

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Liquid formulations containing organic solvents may be flammable.  NO open flames.  Use water spray, dry powder, carbon dioxide. 
EXPLOSION     In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT GENERATION OF MISTS! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Vomiting. Dizziness. Headache. Convulsions. Diarrhoea. Weakness. Laboured breathing. Wheezing. Unconciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes MAY BE ABSORBED! Redness. Pain. Blurred vision.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Diarrhoea. Vomiting. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Give a slurry of activated charcoal in water to drink. Refer for medical attention . See Notes. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Evacuate danger area! Consult an expert! Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Treat remaining liquid with an alkaline substance. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs.
Severe marine pollutant. 
EC Classification
Symbol: T+, N; R: 24-26/28-48/25-50/53; S: (1/2)-28-36/37-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: I 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT6-I.  Provision to contain effluent from fire extinguishing. Separated from strong oxidants and food and feedstuffs. Well closed. Keep in a well-ventilated room. 

IMPORTANT DATA
Physical State; Appearance
PALE YELLOW-TO-BROWN (TECHNICAL-GRADE PRODUCT) LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
No data. 

Chemical dangers
Decomposes above 200°C . This produces toxic gases including carbon monoxide, nitrogen oxides, phosphorous oxides and sulfur oxides. Reacts with strong oxidants. Attacks some forms of plastic, rubber and coatings. 

Occupational exposure limits
TLV (inhalable vapor and aerosol): 0.05mg/m³ as TWA; A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2004).
MAK (inhalable fraction): 0.1 mg/m³; Peak limitation category: II(8); Pregnancy risk group: D; Skin absorption (H); (DFG 2003). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin, by ingestion and through the eyes. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying. 

Effects of short-term exposure
The substance may cause effects on the nervous system. This may result in convulsions, respiratory failure and muscle weakness. Cholinesterase inhibition. Exposure could cause death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 375°C
Melting point: 6°C
Relative density (water = 1): 1.26
Solubility in water, g/100ml at 25°C: 0.002
Flash point: 120°C
Octanol/water partition coefficient as log Pow: 3.8  
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is indicated.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvents also consult the ICSCs of these materials.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Parathion (HSG 74, 1992)
       Parathion (PDS)
       Parathion (FAO Meeting Report PL/1965/10/1)
       Parathion (FAO/PL:1967/M/11/1)
       Parathion (FAO/PL:1969/M/17/1)
       Parathion (AGP:1970/M/12/1)
       Parathion (Pesticide residues in food: 1984 evaluations)
       Parathion (Pesticide residues in food: 1995 evaluations Part II Toxicological & Environmental)
       Parathion (IARC Summary & Evaluation, Volume 30, 1983)