VOL.: 40 (1986) (p. 83)
Chem. Abstr. Name: 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
No adequate data were available to evaluate the reproductive effects or prenatal toxicity of patulin to experimental animals.
Patulin induced DNA damage in Bacillus subtilis, but not in Escherichia coli. It was not mutagenic to Salmonella typhimurium. Patulin induced petite mutants but not mitotic recombination in Saccharomyces cerevisiae. The compound induced DNA strand breaks in HeLa cells, but not unscheduled DNA synthesis in cultured mammalian cells. It induced sister chromatid exchanges in cultured mammalian cells. Patulin induced chromosomal aberrations but not sister chromatid exchanges in the bone-marrow cells of Chinese hamsters treated in vivo. It did not induce dominant lethal mutations in rats or mice.
No evaluation could be made of the carcinogenicity of patulin to humans.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 10 (1976)
Subsequent evaluation: Suppl. 7 (1987) (p. 69: Group 3)
See Also: Toxicological Abbreviations Patulin (WHO Food Additives Series 26) Patulin (WHO Food Additives Series 35) PATULIN (JECFA Evaluation)