VOL.: 40 (1986) (p. 123)
Chem. Abstr. Name: (1,1-Dimethylethyl)-4-methoxyphenol
Butylated hydroxyanisole was studied in mice and rats for its ability to modify the carcinogenicity of selected chemical agents. When administered with known carcinogens, butylated hydroxyanisole either enhanced, inhibited or had no effect on carcinogenicity.
Butylated hydroxyanisole administered to rats at maternally toxic and occasionally lethal doses during, or before, during and after, gestation induced slight embryotoxicity but no definite indication of teratogenicity. No effect was seen in rabbits, pigs or rhesus monkeys.
In rats, feeding of butylated hydroxyanisole in the diet caused superficial necrosis, ulceration and hyperplasia of the squamous epithelium of the forestomach. Induction of forestomach hyperplasia also occurs in hamsters. Administration of butylated hydroxyanisole by gavage to monkeys was associated with an elevated mitotic index in the squamous epithelium of the distal oesophagus.
Butylated hydroxyanisole was not mutagenic to Salmonella typhimurium, Drosophila melanogaster or to Chinese hamster cells in vitro. It did not cause chromosomal effects in D. melanogaster or in cultured Chinese hamster cells.
When tested in combination with other chemicals (usually known mutagens or carcinogens), butylated hydroxyanisole often modified their DNA damaging, mutagenic and clastogenic activities. In most studies, butylated hydroxyanisole reduced the activity of indirectly-acting mutagens/carcinogens.
No data were available on the carcinogenicity of butylated hydroxyanisole to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 59: Group 2B)
See Also: Toxicological Abbreviations Butylated hydroxyanisole (BHA) (WHO Food Additives Series 15) Butylated hydroxyanisole (BHA) (WHO Food Additives Series 18) Butylated hydroxyanisole (BHA) (WHO Food Additives Series 42)