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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

LAUROYL PEROXIDE

VOL.: 36 (1985) (p. 315)

CAS No.: 105-74-8

5. Summary of Data Reported and Evaluation

5.1 Exposure data

Lauroyl peroxide was first produced commercially in about 1941. It is used principally in the production of polymers; small amounts are employed in food packaging.

5.2 Experimental data

Lauroyl peroxide was tested by subcutaneous administration in mice and rats and by skin application in mice. In one study in mice by subcutaneous administration, the evidence concerning a carcinogenic effect was inconclusive; in two other studies, no increase in tumour incidence was observed. Two studies in mice by skin application were inadequate for an evaluation of complete carcinogenicity; one study indicated that lauroyl peroxide has promoting activity in mouse skin.

The available data are inadequate to evaluate the teratogenic potential of lauroyl peroxide in mammals.

The available data are inadequate to evaluate the activity in short-term tests of lauroyl peroxide.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of lauroyl peroxide to humans was available to the Working Group.

5.4 Evaluation

There is inadequate evidence for the carcinogenicity of lauroyl peroxide to experimental animals.

In the absence of epidemiological data, no evaluation could be made of the carcinogenicity of lauroyl peroxide to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonyms


Last updated: 13 April 1999






















    See Also:
       Toxicological Abbreviations
       Lauroyl Peroxide  (IARC Summary & Evaluation, Volume 71, 1999)