International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 283)
CAS No.: 224-42-0
Chem. Abstr. Name: Dibenz(a,j)acridine
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Dibenz[a,j]acridine has been shown to be carcinogenic to
No data on the teratogenicity of this compound were available.
Dibenz[a,j]acridine was mutagenic to Salmonella typhimurium in
the presence of an exogenous metabolic system. It did not induce
unscheduled DNA synthesis in rat hepatocytes.
There is inadequate evidence that dibenz[a,j]acridine is active
in short-term tests.
5.2 Human data
Dibenz[a,j]acridine occurs in tobacco smoke and urban pollutants.
There is sufficient evidence that dibenz[a,j]acridine is
carcinogenic to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 2B)
Last updated: 17 April 1998