International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 155)
CAS No.: 205-82-3
Chem. Abstr. Name: Benzo(j)fluoranthene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Benzo[j]fluoranthene was tested for carcinogenicity in female
mice by skin application and produced benign and malignant skin
tumours. It was also tested in a mouse-skin initiation-promotion
assay and was active as an initiator. In one study in rats involving
direct injection of benzo[j]fluoranthene into the pulmonary tissue, it
produced squamous-cell carcinomas in a dose-related manner.
No study on the teratogenicity of this compound was available.
In the one available study, benzo[j]fluoranthene was mutagenic to
Salmonella typhimurium in the presence of an exogenous metabolic
There is inadequate evidence that benzo[j]fluoranthene is active
in short-term tests.
5.2 Human data
Benzo[j]fluoranthene is present as a component of the total
content of polynuclear aromatic compounds of the environment. Human
exposure to benzo[j]fluoranthene occurs primarily through the smoking
of tobacco, inhalation of polluted air and by ingestion of food and
water contaminated by combustion effluents.
There is sufficient evidence that benzo[j]fluoranthene is
carcinogenic to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 2B)
Last updated: 17 April 1998